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Peptide record

TPDB08674

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB08674
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GRLKRLRKKLKKLLKKLS
Physicochemical Analysis
C101H196N34O20
ANDCEQHIMFPTWYV
K
2206.88
12.73
10
0
6
+10
6.14
-1.067
130.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
6
L
7
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 6 K: 7 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C101H196N34O20
2206.88
12.73
+10
6.14
-1.067
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µM

Target

Staphylococcus aureus MRSA

Source & Reference

NA

Other

Active against S. aureus MRSA (MIC 16 uM). Also inhibit biofilm formation at MBIC 16 uM and disrupted preformed biofilms at MBEC=8
Evidence 2 Activity

Activity

<10% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
<10% Hemolysis | 64 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Multifunctional Properties of BMAP-18 and Its Aliphatic Analog against Drug-Resistant Bacteria. | Pharmaceuticals (Basel) | 2023
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
300 µM
Hemolytic Cytotoxic
10% Hemolysis | 300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cell selectivity, mechanism of action and LPS-neutralizing activity of bovine myeloid antimicrobial peptide-18 (BMAP-18) and its analogs. | Peptides | 2011