Back to search

Peptide record

TPDB08669

Antibacterial Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08669
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 17-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
AAKKGCWTVSIPPKPCF
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C85H133N21O20S2
RNDEQHLMY
KP
1833.24
9.80
3
0
6
+3
0.07
0.047
51.76
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5625
3.07
4
Residue Composition
number
2
A
0
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
1
I
0
L
3
K
0
M
1
F
3
P
1
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 3 M: 0 F: 1 P: 3 S: 1 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
17 reviewed residue count
C85H133N21O20S2 sequence-only estimate (linear, free termini)
1833.24 sequence-only estimate (linear, free termini)
9.80 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.07 sequence-only estimate (linear, free termini)
0.047 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>1000 µM
Hemolytic Cytotoxic
50% Hemolysis | >1000 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Selection and redesign for high selectivity of membrane-active antimicrobial peptides from a dedicated sequence/function database. | Biochim Biophys Acta | 2019