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Peptide record

TPDB08659

Antibacterial Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08659
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 17-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
CGIYRSLKLIKSLVLIK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C91H163N23O21S1
ANDEQHMFPTW
L
1947.50
10.46
4
0
9
+4
-0.13
0.935
177.65
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
0.77
4
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
0
E
0
Q
1
G
0
H
3
I
4
L
3
K
0
M
0
F
0
P
2
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 4 K: 3 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
17 reviewed residue count
C91H163N23O21S1 sequence-only estimate (linear, free termini)
1947.50 sequence-only estimate (linear, free termini)
10.46 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
-0.13 sequence-only estimate (linear, free termini)
0.935 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Bovine erythrocytes

Target

Bovine erythrocytes

Source & Reference

NA
DBAASP
New Synthetic Peptides Conjugated to Gold Nanoclusters: Antibiotic Activity Against Escherichia coli O157:H7 and Methicillin-Resistant Staphylococcus aureus (MRSA). | Protein J | 2019
Evidence 2 Activity

Activity

32% Cytotoxicity
Toxicity
30-100 µM
Cytotoxic
32% Cytotoxicity | 30-100 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
New Synthetic Peptides Conjugated to Gold Nanoclusters: Antibiotic Activity Against Escherichia coli O157:H7 and Methicillin-Resistant Staphylococcus aureus (MRSA). | Protein J | 2019
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31119600] No hemolytic activity against bovine blood cells | Cytotoxicity: [Ref.31119600] The cell viability of Vero ATCC CCL 1-81 cells induced by NBC2253 is 87.8%, 66.4%, 62.2%, 69.1% and 68.8% at peptide concentrations of 1.2, 3.7, 11.1, 33.3 and 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Protein J. 2019 May 22. doi: 10.1007/s10930-019-09840-9.