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Peptide record

TPDB08657

Antibacterial Antifungal standard

17 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB08657

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

GFWNVVYRNGVRVHRRN

FASTA

>TPDB08657|Antibacterial;Antifungal|length=17
GFWNVVYRNGVRVHRRN

Formula C95H145N35O22

Absent Amino Acids ADCEQILKMPST

Common Amino Acids RV

Mass 2129.42

PI 12.40

Basic Residues 5

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +4

Boman Index 1.84

Hydrophobicity -0.888

Aliphatic Index 68.24

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 6990

Absorbance 280nm 328.26

Polar Residues 4

number

Amino Acid Distribution

A: 0 R: 4 N: 3 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 4

Length

Formula

C95H145N35O22

Mass

2129.42

12.40

Net Charge

Boman Index

1.84

Hydrophobicity

-0.888

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism S.typhimurium ATCC14028

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

m- bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7 (MIC 64-128 ug/ml), S.typhimurium ATCC14028 (MIC 128 ug/ml), S. enteritidis CVCC3377 (MIC 4 ug/ml), S.pullorum CVCC1789 or CVCC1802 (MIC >128 ug/ml),

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism S. enteritidis CVCC3377

Source & Reference

Database Source dbAMP

Other

Evidence Text

r CICC21530 serotype O157:H7 (MIC 64-128 ug/ml), S.typhimurium ATCC14028 (MIC 128 ug/ml), S. enteritidis CVCC3377 (MIC 4 ug/ml), S.pullorum CVCC1789 or CVCC1802 (MIC >128 ug/ml), S.choleraesuis CVCC503 (MIC >128 ug/ml

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.pullorum CVCC1789 or CVCC1802

Source & Reference

Database Source dbAMP

Other

Evidence Text

8 ug/ml), S.typhimurium ATCC14028 (MIC 128 ug/ml), S. enteritidis CVCC3377 (MIC 4 ug/ml), S.pullorum CVCC1789 or CVCC1802 (MIC >128 ug/ml), S.choleraesuis CVCC503 (MIC >128 ug/ml), P.aeruginosa CICC10419 or CICC21630 (MIC >128 u

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.choleraesuis CVCC503

Source & Reference

Database Source dbAMP

Other

Evidence Text

S. enteritidis CVCC3377 (MIC 4 ug/ml), S.pullorum CVCC1789 or CVCC1802 (MIC >128 ug/ml), S.choleraesuis CVCC503 (MIC >128 ug/ml), P.aeruginosa CICC10419 or CICC21630 (MIC >128 ug/ml), Gram+ S. aureus ATCC25923 (MIC 2 u

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism P.aeruginosa CICC10419 or CICC21630

Source & Reference

Database Source dbAMP

Other

Evidence Text

.pullorum CVCC1789 or CVCC1802 (MIC >128 ug/ml), S.choleraesuis CVCC503 (MIC >128 ug/ml), P.aeruginosa CICC10419 or CICC21630 (MIC >128 ug/ml), Gram+ S. aureus ATCC25923 (MIC 2 ug/ml) or S.aureus ATCC43300 MRSA (MIC > 128 ug/ml) (MR

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP

Other

Evidence Text

uis CVCC503 (MIC >128 ug/ml), P.aeruginosa CICC10419 or CICC21630 (MIC >128 ug/ml), Gram+ S. aureus ATCC25923 (MIC 2 ug/ml) or S.aureus ATCC43300 MRSA (MIC > 128 ug/ml) (MRSA-inactive), S.suis CVCC606 (MIC >128 ug

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.suis CVCC606

Source & Reference

Database Source dbAMP

Other

Evidence Text

eus ATCC25923 (MIC 2 ug/ml) or S.aureus ATCC43300 MRSA (MIC > 128 ug/ml) (MRSA-inactive), S.suis CVCC606 (MIC >128 ug/ml), E. faecium CMCC1.2136 (MIC 64 ug/ml), B. subtilis ATCC6633 (MIC 64 ug/ml), L.ivanovii AT

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism B. subtilis ATCC6633

Source & Reference

Database Source dbAMP

Other

Evidence Text

) (MRSA-inactive), S.suis CVCC606 (MIC >128 ug/ml), E. faecium CMCC1.2136 (MIC 64 ug/ml), B. subtilis ATCC6633 (MIC 64 ug/ml), L.ivanovii ATCC19119 (MIC 128 ug/ml), fungi C.albicans CGMCC2.2411 (MIC >128 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism L.ivanovii ATCC19119

Source & Reference

Database Source dbAMP

Other

Evidence Text

C >128 ug/ml), E. faecium CMCC1.2136 (MIC 64 ug/ml), B. subtilis ATCC6633 (MIC 64 ug/ml), L.ivanovii ATCC19119 (MIC 128 ug/ml), fungi C.albicans CGMCC2.2411 (MIC >128 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 128 µg/mL

Target

Target Organism S.typhimurium ATCC14028

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism S. enteritidis CVCC3377

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism S.pullorum CVCC1789 or CVCC1802

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism S.choleraesuis CVCC503

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism P.aeruginosa CICC10419 or CICC21630

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism Staphylococcus aureus ATCC25923

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism S.suis CVCC606

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64 µg/mL

Target

Target Organism B. subtilis ATCC6633

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 128 µg/mL

Target

Target Organism L.ivanovii ATCC19119

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

C >128 ug/ml), E. faecium CMCC1.2136 (MIC 64 ug/ml), B. subtilis ATCC6633 (MIC 64 ug/ml), L.ivanovii ATCC19119 (MIC 128 ug/ml), fungi C.albicans CGMCC2.2411 (MIC >128 ug/ml).