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Peptide record

TPDB08656

Antibacterial Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08656
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 17-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
VCKRWKKWKRKWKKWCV
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C114H178N34O18S2
ANDEQGHILMFPSTY
K
2377.00
11.23
9
0
6
+9
2.87
-1.559
34.12
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
22125
9.31
2
Residue Composition
number
0
A
2
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
0
I
0
L
7
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 7 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 2
Chemical Descriptors
17 reviewed residue count
C114H178N34O18S2 sequence-only estimate (linear, free termini)
2377.00 sequence-only estimate (linear, free termini)
11.23 sequence-only estimate (linear, free termini)
+9 sequence-only estimate (linear, free termini)
2.87 sequence-only estimate (linear, free termini)
-1.559 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>320 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | >320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection. | Proc Natl Acad Sci U S A | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>320 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection. | Proc Natl Acad Sci U S A | 2019
Evidence 3 Activity

Activity

3.1±1.2% Hemolysis
Toxicity
320 µg/mL
Hemolytic Cytotoxic
3.1±1.2% Hemolysis | 320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection. | Proc Natl Acad Sci U S A | 2019
Evidence 4 Activity

Activity

10% Killing
Toxicity
80 µM
Cytotoxic
10% Killing | 80 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection. | Proc Natl Acad Sci U S A | 2019
Evidence 5 Activity

Activity

15% Killing
Toxicity
80 µM
Cytotoxic
15% Killing | 80 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection. | Proc Natl Acad Sci U S A | 2019