TPDB

3D PDB MODEL

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TPDB ID TPDB08641

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 SATPdb iACP-DRLF pep-lab AFP-GFuse Antifp HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FVDLKKIANIINSIFGK

FASTA

>TPDB08641|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=17
FVDLKKIANIINSIFGK

Formula C91H150N22O23

Absent Amino Acids RCEQHMPTWY

Common Amino Acids I

Mass 1920.33

PI 10.32

Basic Residues 3

Acidic Residues 1

Hydrophobic Residues 9

Net Charge +2

Boman Index 1.02

Hydrophobicity 0.588

Aliphatic Index 137.65

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 3

number

1

A

0

R

2

N

1

D

0

C

0

E

0

Q

1

G

0

H

4

I

1

L

3

K

0

M

2

F

0

P

1

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 1 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 4 L: 1 K: 3 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

17

Formula

C91H150N22O23

Mass

1920.33

PI

10.32

Net Charge

+2

Boman Index

1.02

Hydrophobicity

0.588

Evidence 1 Activity

Activity

Detail Source Activity Hemolysis

Hemolysis Raw

[Ref:21871946]LD50=99.08 µM against human erythrocytes

Target

RBC Target human erythrocytes

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

Biochimie. 2012 Feb 94(2):434-441.##Zoolog Sci. 2009 Mar 26(3):220-226.

Other

Source Activity Label	Source Definition
Hemolysis	Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 99.08 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 99.08 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antitumor effects and cell selectivity of temporin-1CEa, an antimicrobial peptide from the skin secretions of the Chinese brown frog (Rana chensinensis). | Biochimie | 2012

Evidence 3 Activity

Activity

Activity Endpoint 97.4-100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 375 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

97.4-100% Hemolysis | 375 | µM | target cell: Horse erythrocytes

Target

Target Cell Horse erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Antimicrobial peptide KSL-W and analogues: Promising agents to control plant diseases. | Peptides | 2018

Evidence 4 Activity

Activity

Activity Endpoint LD50

Detail Source Activity Toxicity

Activity Measurement 99.08 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:21871946]LD50=99.08 µM against human erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Biochimie. 2012 Feb 94(2):434-441.##Zoolog Sci. 2009 Mar 26(3):220-226.

Evidence 5 Hemolysis

Activity

Hemolysis Raw

[Ref:21871946]LD50=99.08 µM against human erythrocytes

Detail Source Activity Hemolysis

Target

RBC Target human erythrocytes

Source & Reference

source HemoPI PD_Hemolysis

Reference

Biochimie. 2012 Feb 94(2):434-441.##Zoolog Sci. 2009 Mar 26(3):220-226.

Source DRAMP4

Database Source PD_Hemolysis