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Peptide record

TPDB08637

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

17 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB08637

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

AAPRGGKGFFCKLFKDC

FASTA

>TPDB08637|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=17
AAPRGGKGFFCKLFKDC

Formula C84H129N23O20S2

Absent Amino Acids NEQHIMSTWYV

Common Amino Acids GKF

Mass 1845.21

PI 9.80

Basic Residues 4

Acidic Residues 1

Hydrophobic Residues 6

Net Charge +3

Boman Index 0.72

Hydrophobicity -0.100

Aliphatic Index 34.71

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.77

Polar Residues 2

number

Amino Acid Distribution

A: 2 R: 1 N: 0 D: 1 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 1 K: 3 M: 0 F: 3 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C84H129N23O20S2

Mass

1845.21

9.80

Net Charge

Boman Index

0.72

Hydrophobicity

-0.100

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

weakly active against B. pyocyaneus (p. aeruginosa) (MIC 50 ug/ml), E. coli (MIC 100 ug/ml), S. aureus (MIC 50 ug/ml), and C. albicans (MIC 100 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

kly active against B. pyocyaneus (p. aeruginosa) (MIC 50 ug/ml), E. coli (MIC 100 ug/ml), S. aureus (MIC 50 ug/ml), and C. albicans (MIC 100 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

us (p. aeruginosa) (MIC 50 ug/ml), E. coli (MIC 100 ug/ml), S. aureus (MIC 50 ug/ml), and C. albicans (MIC 100 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

weakly active against B. pyocyaneus (p. aeruginosa) (MIC 50 ug/ml), E. coli (MIC 100 ug/ml), S. aureus (MIC 50 ug/ml), and C. albicans (MIC 100 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

kly active against B. pyocyaneus (p. aeruginosa) (MIC 50 ug/ml), E. coli (MIC 100 ug/ml), S. aureus (MIC 50 ug/ml), and C. albicans (MIC 100 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

us (p. aeruginosa) (MIC 50 ug/ml), E. coli (MIC 100 ug/ml), S. aureus (MIC 50 ug/ml), and C. albicans (MIC 100 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

weakly active against B. pyocyaneus (p. aeruginosa) (MIC 50 ug/ml), E. coli (MIC 100 ug/ml), S. aureus (MIC 50 ug/ml), and C. albicans (MIC 100 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

kly active against B. pyocyaneus (p. aeruginosa) (MIC 50 ug/ml), E. coli (MIC 100 ug/ml), S. aureus (MIC 50 ug/ml), and C. albicans (MIC 100 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

us (p. aeruginosa) (MIC 50 ug/ml), E. coli (MIC 100 ug/ml), S. aureus (MIC 50 ug/ml), and C. albicans (MIC 100 ug/ml).

Evidence 10 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

- | NA | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Extremely abundant antimicrobial peptides existed in the skins of nine kinds of Chinese odorous frogs. | J Proteome Res | 2012