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Peptide record

TPDB08635

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08635
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF Antifungipept ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFGSLLGKALRLGANVL
Physicochemical Analysis
C77H132N22O20
DCEQHIMPTWY
L
1686.03
11.49
2
0
9
+2
-1.81
0.900
143.53
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
2
A
1
R
1
N
0
D
0
C
0
E
0
Q
4
G
0
H
0
I
5
L
1
K
0
M
1
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 0 L: 5 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C77H132N22O20
1686.03
11.49
+2
-1.81
0.900
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
140 µM
Hemolytic Cytotoxic
50% Hemolysis | 140 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and properties of antimicrobial peptides from skin secretions of the Eritrea clawed frog Xenopus clivii (Pipidae) | Comp Biochem Physiol C Toxicol Pharmacol | 2011
Evidence 2 Activity

Activity

<5% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria | Chem Biol Drug Des | 2017
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria | Chem Biol Drug Des | 2017
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.28371431] 0% hemolysis at 32 µg/ml , 5% hemolysis at 64 µg/ml , 7% hemolysis at 128 µg/ml , 15% hemolysis at 256 µg/ml , 57% hemolysis at 512 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2017 Nov 90(5):690-702. doi: 10.1111/cbdd.12988.