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Peptide record

TPDB08632

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08632
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept dbAMP 3.0 i2APP AI4AVP
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKLFKKIKFLHSAKKF
Physicochemical Analysis
C110H173N27O19
RNDCEQGMPTYV
K
2177.75
11.29
8
0
8
+7
1.18
-0.582
74.71
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
252.55
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
2
L
7
K
0
M
3
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 2 K: 7 M: 0 F: 3 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C110H173N27O19
2177.75
11.29
+7
1.18
-0.582
Evidence Records 25 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 u
Evidence 2 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

S. typhimurium

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K
Evidence 5 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

Streptococcus pyogenes

Source & Reference

dbAMP DRAMP

Other

typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K-562 (IC50 85 uM) and Jurka
Evidence 6 Activity

Activity

MIC
Antibacterial
3.12 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K-562 (IC50 85 uM) and Jurkat (IC50 65 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
6.25 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 u
Evidence 8 Activity

Activity

MIC
Antifungal
0.78 µM

Target

S. typhimurium

Source & Reference

dbAMP DRAMP Antifungipept

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM),
Evidence 9 Activity

Activity

MIC
Antifungal
1.56 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP DRAMP Antifungipept

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
1.56 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP Antifungipept

Other

- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K
Evidence 11 Activity

Activity

MIC
Antifungal
0.78 µM

Target

Streptococcus pyogenes

Source & Reference

dbAMP DRAMP Antifungipept

Other

typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K-562 (IC50 85 uM) and Jurka
Evidence 12 Activity

Activity

MIC
Antifungal
3.12 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K-562 (IC50 85 uM) and Jurkat (IC50 65 uM).
Evidence 13 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 u
Evidence 14 Activity

Activity

MIC
Antiparasitic
0.78 µM

Target

S. typhimurium

Source & Reference

dbAMP 3.0 DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM),
Evidence 15 Activity

Activity

MIC
Antiparasitic
1.56 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM).
Evidence 16 Activity

Activity

MIC
Antiparasitic
1.56 µM

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP

Other

- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K
Evidence 17 Activity

Activity

MIC
Antiparasitic
0.78 µM

Target

Streptococcus pyogenes

Source & Reference

dbAMP 3.0 DRAMP

Other

typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K-562 (IC50 85 uM) and Jurka
Evidence 18 Activity

Activity

MIC
Antiparasitic
3.12 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K-562 (IC50 85 uM) and Jurkat (IC50 65 uM).
Evidence 19 Activity

Activity

MIC
Antiviral
6.25 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 u
Evidence 20 Activity

Activity

MIC
Antiviral
0.78 µM

Target

S. typhimurium

Source & Reference

dbAMP 3.0 DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM),
Evidence 21 Activity

Activity

MIC
Antiviral
1.56 µM

Target

Pseudomonas aeruginosa

Source & Reference

dbAMP 3.0 DRAMP

Other

active against Gram- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM).
Evidence 22 Activity

Activity

MIC
Antiviral
1.56 µM

Target

B. subtilis

Source & Reference

dbAMP 3.0 DRAMP

Other

- E. coli (MIC 6.25 uM), S. typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K
Evidence 23 Activity

Activity

MIC
Antiviral
0.78 µM

Target

Streptococcus pyogenes

Source & Reference

dbAMP 3.0 DRAMP

Other

typhimurium (MIC 0.78 uM), P. aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K-562 (IC50 85 uM) and Jurka
Evidence 24 Activity

Activity

MIC
Antiviral
3.12 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP 3.0 DRAMP

Other

aeruginosa (MIC 1.56 uM), Gram+ B. subtilis (MIC 1.56 uM), S. pyogenes (MIC 0.78 uM), and S. aureus (MIC 3.12 uM). Weak activity to cancer cells: K-562 (IC50 85 uM) and Jurkat (IC50 65 uM).
Evidence 25 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of the hinge region of cecropin A(1-8)-magainin 2(1-12), a synthetic antimicrobial peptide, on liposomes, bacterial and tumor cells. | Biochim Biophys Acta | 2000