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Peptide record

TPDB08628

Dybowskin-2 Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08628
Dybowskin-2
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLIGMTQGLICLITRKC
Physicochemical Analysis
C85H148N22O21S3
ANDEHPSWYV
IL
1910.42
9.15
2
0
8
+2
-1.77
1.206
137.65
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
6.54
5
Residue Composition
number
0
A
1
R
0
N
0
D
2
C
0
E
1
Q
2
G
0
H
3
I
3
L
1
K
1
M
1
F
0
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 2 H: 0 I: 3 L: 3 K: 1 M: 1 F: 1 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C85H148N22O21S3
1910.42
9.15
+2
-1.77
1.206
Free
L
Not Available
Free
Antibacterial
Rana dybowskii, Rana chensinensis, Asia
Evidence Records 36 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.3 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dyse
Evidence 2 Activity

Activity

MIC
Antibacterial
7.9 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E.
Evidence 3 Activity

Activity

MIC
Antibacterial
13.1 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pne
Evidence 4 Activity

Activity

MIC
Antibacterial
13.1 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP

Other

Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirab
Evidence 5 Activity

Activity

MIC
Antibacterial
26.2 µM

Target

S. dysenteriae

Source & Reference

dbAMP DRAMP

Other

3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeru
Evidence 6 Activity

Activity

MIC
Antibacterial
31.4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

M), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml),
Evidence 7 Activity

Activity

MIC
Antibacterial
31.4 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP

Other

6.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Also found by Shang et al. (2009) (ref see AP605), whic
Evidence 9 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Also found by Shang et al. (2009) (ref see AP605), which reported the peptide is active
Evidence 10 Activity

Activity

MIC
Antibacterial
12.8-25.6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

AP605), which reported the peptide is active against S. aureus, B. cereus, S. lactis and E. coli (MIC 12.8-25.6 uM). Found in multiple species.
Evidence 11 Activity

Activity

Not Available
Anticancer

Target

Not Available
Not Available
Not Available

Assay & Model

Not Available
Not Available

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2007

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 12 Activity

Activity

MIC
Antifungal
3.3 µM

Target

M. luteus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dyse
Evidence 13 Activity

Activity

MIC
Antifungal
7.9 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E.
Evidence 14 Activity

Activity

MIC
Antifungal
13.1 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pne
Evidence 15 Activity

Activity

MIC
Antifungal
13.1 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirab
Evidence 16 Activity

Activity

MIC
Antifungal
26.2 µM

Target

S. dysenteriae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeru
Evidence 17 Activity

Activity

MIC
Antifungal
31.4 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml),
Evidence 18 Activity

Activity

MIC
Antifungal
31.4 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/
Evidence 19 Activity

Activity

MIC
Antifungal
>100 µg/mL

Target

P.aeruginosa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

6.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Also found by Shang et al. (2009) (ref see AP605), whic
Evidence 20 Activity

Activity

MIC
Antifungal
100 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Also found by Shang et al. (2009) (ref see AP605), which reported the peptide is active
Evidence 21 Activity

Activity

MIC
Antifungal
12.8-25.6 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

AP605), which reported the peptide is active against S. aureus, B. cereus, S. lactis and E. coli (MIC 12.8-25.6 uM). Found in multiple species.
Evidence 22 Activity

Activity

MIC
Antiparasitic
3.3 µM

Target

M. luteus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dyse
Evidence 23 Activity

Activity

MIC
Antiparasitic
7.9 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E.
Evidence 24 Activity

Activity

MIC
Antiparasitic
13.1 µM

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pne
Evidence 25 Activity

Activity

MIC
Antiparasitic
13.1 µM

Target

Staphylococcus epidermidis

Source & Reference

DRAMP

Other

Active against M. luteus (MIC 3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirab
Evidence 26 Activity

Activity

MIC
Antiparasitic
26.2 µM

Target

S. dysenteriae

Source & Reference

DRAMP

Other

3.3 uM), S. aureus (MIC 7.9 uM), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeru
Evidence 27 Activity

Activity

MIC
Antiparasitic
31.4 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

M), B. subtilis (MIC 13.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml),
Evidence 28 Activity

Activity

MIC
Antiparasitic
31.4 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

.1 uM), S. epidermidis (MIC 13.1 uM), S. dysenteriae (MIC 26.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/
Evidence 29 Activity

Activity

MIC
Antiparasitic
>100 µg/mL

Target

P.aeruginosa

Source & Reference

DRAMP

Other

6.2uM), E. coli (MIC 31.4 uM), K. pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Also found by Shang et al. (2009) (ref see AP605), whic
Evidence 30 Activity

Activity

MIC
Antiparasitic
100 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

pneumoniae (MIC 31.4 uM), P.mirabilis (MIC> 100 ug/ml), P.aeruginosa (MIC>100 ug/ml), and C. albicans (MIC 100 ug/ml). Also found by Shang et al. (2009) (ref see AP605), which reported the peptide is active
Evidence 31 Activity

Activity

MIC
Antiparasitic
12.8-25.6 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

AP605), which reported the peptide is active against S. aureus, B. cereus, S. lactis and E. coli (MIC 12.8-25.6 uM). Found in multiple species.
Evidence 32 Activity

Activity

% Hemolysis
Hemolysis
10.99 %
[Ref:17698251] It has 10.99% hemolytic activity at 100 µg/ml against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete PD_Hemolysis
DRAMP4
Peptides 2007 28: 1532-1539.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 33 Activity

Activity

11% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
11% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification and characterization of antimicrobial peptides from the skin secretion of Rana dybowskii. | Peptides | 2007
Evidence 34 Activity

Activity

50% Hemolysis
Toxicity
48 µM
Hemolytic Cytotoxic
50% Hemolysis | 48 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular cloning of cDNAs encoding antimicrobial peptide precursors from the skin of the Chinese brown frog, Rana chensinensis. | Zoolog Sci | 2009
Evidence 35 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref:17698251] It has 10.99% hemolytic activity at 100 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides 2007 28: 1532-1539.
Evidence 36 Hemolysis

Activity

10.99 %
% Hemolysis
[Ref:17698251] It has 10.99% hemolytic activity at 100 µg/ml against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete HemoPI PD_Hemolysis
Peptides 2007 28: 1532-1539.
DRAMP4
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.