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Peptide record

TPDB08627

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08627
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWCFRVCYRGICYRKCR
Physicochemical Analysis
C99H154N32O20S4
ANDEQHLMPST
RC
2240.75
10.00
6
0
6
+6
-0.83
-0.482
40.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8730
389.60
6
Residue Composition
number
0
A
4
R
0
N
0
D
4
C
0
E
0
Q
1
G
0
H
1
I
0
L
2
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
17
C99H154N32O20S4
2240.75
10.00
+6
-0.83
-0.482
Evidence Records 30 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.0 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853 planktonic cells

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against P. aeruginosa ATCC 27853 planktonic cells (MIC 2.0ug/ml) and P. aeruginosa ATCC 27853 adherent cells (MIC 4.0ug/ml). Also active against E. coli D
Evidence 2 Activity

Activity

MIC
Antibacterial
4.0 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853 adherent cells

Source & Reference

dbAMP DRAMP

Other

Active against P. aeruginosa ATCC 27853 planktonic cells (MIC 2.0ug/ml) and P. aeruginosa ATCC 27853 adherent cells (MIC 4.0ug/ml). Also active against E. coli DC2 CGSC 7139, E. coli ATCC 25922 (MIC 0.0625-0.5 uM), S. au
Evidence 3 Activity

Activity

MIC
Antibacterial
0.0625-0.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

nosa ATCC 27853 adherent cells (MIC 4.0ug/ml). Also active against E. coli DC2 CGSC 7139, E. coli ATCC 25922 (MIC 0.0625-0.5 uM), S. aureus ATCC 25923, and S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albic
Evidence 4 Activity

Activity

MIC
Antibacterial
1-8 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP

Other

E. coli DC2 CGSC 7139, E. coli ATCC 25922 (MIC 0.0625-0.5 uM), S. aureus ATCC 25923, and S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM),
Evidence 5 Activity

Activity

MIC
Antibacterial
14.28 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP

Other

-0.5 uM), S. aureus ATCC 25923, and S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC2
Evidence 6 Activity

Activity

MIC
Antibacterial
28.56 µM

Target

C. krusei IFM56881

Source & Reference

dbAMP DRAMP

Other

S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC22019 (MIC 7.14 uM) ( Zhang et al.,
Evidence 7 Activity

Activity

MIC
Antibacterial
1.79 µM

Target

C. neoformans H99

Source & Reference

dbAMP DRAMP

Other

Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC22019 (MIC 7.14 uM) ( Zhang et al., 2022 ). Antibiofilm:bacteria: in
Evidence 8 Activity

Activity

MIC
Antibacterial
7.14 µM

Target

C. parapsilosis ATCC22019

Source & Reference

dbAMP DRAMP

Other

SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC22019 (MIC 7.14 uM) ( Zhang et al., 2022 ). Antibiofilm:bacteria: inhibited bacterial biofilm:P. aeruginosa w
Evidence 9 Activity

Activity

MIC
Antifungal
2.0 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853 planktonic cells

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against P. aeruginosa ATCC 27853 planktonic cells (MIC 2.0ug/ml) and P. aeruginosa ATCC 27853 adherent cells (MIC 4.0ug/ml). Also active against E. coli D
Evidence 10 Activity

Activity

MIC
Antifungal
4.0 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853 adherent cells

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against P. aeruginosa ATCC 27853 planktonic cells (MIC 2.0ug/ml) and P. aeruginosa ATCC 27853 adherent cells (MIC 4.0ug/ml). Also active against E. coli DC2 CGSC 7139, E. coli ATCC 25922 (MIC 0.0625-0.5 uM), S. au
Evidence 11 Activity

Activity

MIC
Antifungal
0.0625-0.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

nosa ATCC 27853 adherent cells (MIC 4.0ug/ml). Also active against E. coli DC2 CGSC 7139, E. coli ATCC 25922 (MIC 0.0625-0.5 uM), S. aureus ATCC 25923, and S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albic
Evidence 12 Activity

Activity

MIC
Antifungal
1-8 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

E. coli DC2 CGSC 7139, E. coli ATCC 25922 (MIC 0.0625-0.5 uM), S. aureus ATCC 25923, and S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM),
Evidence 13 Activity

Activity

MIC
Antifungal
14.28 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

-0.5 uM), S. aureus ATCC 25923, and S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC2
Evidence 14 Activity

Activity

MIC
Antifungal
28.56 µM

Target

C. krusei IFM56881

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC22019 (MIC 7.14 uM) ( Zhang et al.,
Evidence 15 Activity

Activity

MIC
Antifungal
1.79 µM

Target

C. neoformans H99

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC22019 (MIC 7.14 uM) ( Zhang et al., 2022 ). Antibiofilm:bacteria: in
Evidence 16 Activity

Activity

MIC
Antifungal
7.14 µM

Target

C. parapsilosis ATCC22019

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC22019 (MIC 7.14 uM) ( Zhang et al., 2022 ). Antibiofilm:bacteria: inhibited bacterial biofilm:P. aeruginosa w
Evidence 17 Activity

Activity

MIC
Antiparasitic
2.0 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853 planktonic cells

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against P. aeruginosa ATCC 27853 planktonic cells (MIC 2.0ug/ml) and P. aeruginosa ATCC 27853 adherent cells (MIC 4.0ug/ml). Also active against E. coli D
Evidence 18 Activity

Activity

MIC
Antiparasitic
4.0 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853 adherent cells

Source & Reference

DRAMP

Other

Active against P. aeruginosa ATCC 27853 planktonic cells (MIC 2.0ug/ml) and P. aeruginosa ATCC 27853 adherent cells (MIC 4.0ug/ml). Also active against E. coli DC2 CGSC 7139, E. coli ATCC 25922 (MIC 0.0625-0.5 uM), S. au
Evidence 19 Activity

Activity

MIC
Antiparasitic
0.0625-0.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

nosa ATCC 27853 adherent cells (MIC 4.0ug/ml). Also active against E. coli DC2 CGSC 7139, E. coli ATCC 25922 (MIC 0.0625-0.5 uM), S. aureus ATCC 25923, and S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albic
Evidence 20 Activity

Activity

MIC
Antiparasitic
1-8 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

DRAMP

Other

E. coli DC2 CGSC 7139, E. coli ATCC 25922 (MIC 0.0625-0.5 uM), S. aureus ATCC 25923, and S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM),
Evidence 21 Activity

Activity

MIC
Antiparasitic
14.28 µM

Target

Candida albicans SC5314

Source & Reference

DRAMP

Other

-0.5 uM), S. aureus ATCC 25923, and S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC2
Evidence 22 Activity

Activity

MIC
Antiparasitic
28.56 µM

Target

C. krusei IFM56881

Source & Reference

DRAMP

Other

S. aureus ATCC 6538 (MIC 1-8 uM). Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC22019 (MIC 7.14 uM) ( Zhang et al.,
Evidence 23 Activity

Activity

MIC
Antiparasitic
1.79 µM

Target

C. neoformans H99

Source & Reference

DRAMP

Other

Also active against C. albicans SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC22019 (MIC 7.14 uM) ( Zhang et al., 2022 ). Antibiofilm:bacteria: in
Evidence 24 Activity

Activity

MIC
Antiparasitic
7.14 µM

Target

C. parapsilosis ATCC22019

Source & Reference

DRAMP

Other

SC5314 (MIC 14.28 uM), C. krusei IFM56881(MIC 28.56 uM), C. neoformans H99 (MIC 1.79 uM), C. parapsilosis ATCC22019 (MIC 7.14 uM) ( Zhang et al., 2022 ). Antibiofilm:bacteria: inhibited bacterial biofilm:P. aeruginosa w
Evidence 25 Activity

Activity

20% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
20% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III | Mar Drugs | 2018
Evidence 26 Activity

Activity

IC50
Toxicity
19.7±1.9 µM
Cytotoxic
IC50 | 19.7±1.9 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III | Mar Drugs | 2018
Evidence 27 Activity

Activity

IC50
Toxicity
14.1±1.2 µM
Cytotoxic
IC50 | 14.1±1.2 | µM | target cell: Human embryonic fibroblasts

Target

Human embryonic fibroblasts

Source & Reference

NA
DBAASP
Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III | Mar Drugs | 2018
Evidence 28 Activity

Activity

IC50
Toxicity
21.3±1.2 µM
Cytotoxic
IC50 | 21.3±1.2 | µM | target cell: Human normal astrocytes

Target

Human normal astrocytes

Source & Reference

NA
DBAASP
Cytotoxic Potential of the Novel Horseshoe Crab Peptide Polyphemusin III | Mar Drugs | 2018
Evidence 29 Activity

Activity

50% Hemolysis
Toxicity
86.4±12.2 µM
Hemolytic Cytotoxic
50% Hemolysis | 86.4±12.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties. | Int J Mol Sci | 2019
Evidence 30 Activity

Activity

50% Cell death
Toxicity
7.3±0.5 µM
Cytotoxic
50% Cell death | 7.3±0.5 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Characterization of Tachyplesin Peptides and Their Cyclized Analogues to Improve Antimicrobial and Anticancer Properties. | Int J Mol Sci | 2019