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Peptide record

TPDB08620

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08620
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AAKIILNPKFRCKAAFC
Physicochemical Analysis
C87H144N24O19S2
DEQGHMSTWYV
A
1894.37
10.32
4
0
9
+4
0.05
0.547
92.35
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
125
6.60
3
Residue Composition
number
4
A
1
R
1
N
0
D
2
C
0
E
0
Q
0
G
0
H
2
I
1
L
3
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 3 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C87H144N24O19S2
1894.37
10.32
+4
0.05
0.547
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
30 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 30 uM). A change of the last K to F reduced activity (MIC 160 uM). CKAAFC itself is not antimicr
Evidence 2 Activity

Activity

MIC
Antifungal
30 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 30 uM). A change of the last K to F reduced activity (MIC 160 uM). CKAAFC itself is not antimicr
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
10% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational Design of Short Peptide Variants by Using Kunitzin-RE, an Amphibian-Derived Bioactivity Peptide, for Acquired Potent Broad-Spectrum Antimicrobial and Improved Therapeutic Potential of Commensalism Coinfection of Pathogens. | J Med Chem | 2019
Evidence 4 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Kunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs. | Biochem Biophys Res Commun | 2016
Evidence 5 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.