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Peptide record

TPDB08619

Antibacterial Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08619
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KKKKKKAAFAAWAAFAA
Physicochemical Analysis
C89H142N24O18
RNDCEQGHILMPSTYV
A
1836.26
11.21
6
0
11
+6
0.47
-0.253
47.06
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
299.52
0
Residue Composition
number
8
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
6
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C89H142N24O18
1836.26
11.21
+6
0.47
-0.253
Evidence Records 4 records
Evidence 1 Activity

Activity

1% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
1% Hemolysis | 200 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Cationic hydrophobic peptides with antimicrobial activity | Antimicrob Agents Chemother | 2002
Evidence 2 Activity

Activity

0% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0% Hemolysis | 50 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Cationic hydrophobic peptides with antimicrobial activity | Antimicrob Agents Chemother | 2002
Evidence 3 Activity

Activity

0% Hemolysis
Toxicity
50-200 µM
Hemolytic Cytotoxic
0% Hemolysis | 50-200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 4 Activity

Activity

MHC
Toxicity
320 µM
Hemolytic
Hemolytic_activity: [Ref.29275987] MHC = 320 µM against human red blood cells. Note: Minimum hemolytic concentration (MHC) is the minimum peptide concentration at which red blood cells undergo > 2% hemolysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioorg Med Chem. 2018 Mar 15 26(6):1189-1196. doi: 10.1016/j.bmc.2017.10.020. Epub 2017 Oct 21.