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Peptide record

TPDB08608

Antibacterial Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08608
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPLFLPKIICVITKKC
Physicochemical Analysis
C97H162N20O19S2
ARNDEQGHMSWY
ILK
1976.60
9.80
3
0
9
+3
-1.27
1.418
154.71
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
125
6.32
3
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
3
I
3
L
3
K
0
M
2
F
2
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 3 K: 3 M: 0 F: 2 P: 2 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C97H162N20O19S2
1976.60
9.80
+3
-1.27
1.418
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>200 µg/mL

Target

E.coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E.coli ATCC 25922 (MIC >200 ug/ml), B. dysenteriae (MIC 35 ug/ml), S. aureus ATCC 2592 (MIC 4.7 ug/ml), B. subtilis ATCC 663
Evidence 2 Activity

Activity

MIC
Antibacterial
35 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP

Other

Active against E.coli ATCC 25922 (MIC >200 ug/ml), B. dysenteriae (MIC 35 ug/ml), S. aureus ATCC 2592 (MIC 4.7 ug/ml), B. subtilis ATCC 6633 (MIC 9.38 ug/ml), and fungi C
Evidence 3 Activity

Activity

MIC
Antibacterial
4.7 µg/mL

Target

Staphylococcus aureus ATCC 2592

Source & Reference

dbAMP DRAMP

Other

Active against E.coli ATCC 25922 (MIC >200 ug/ml), B. dysenteriae (MIC 35 ug/ml), S. aureus ATCC 2592 (MIC 4.7 ug/ml), B. subtilis ATCC 6633 (MIC 9.38 ug/ml), and fungi C. albicans ATCC 2002 (MIC 18.75 ug/ml
Evidence 4 Activity

Activity

MIC
Antibacterial
9.38 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP

Other

922 (MIC >200 ug/ml), B. dysenteriae (MIC 35 ug/ml), S. aureus ATCC 2592 (MIC 4.7 ug/ml), B. subtilis ATCC 6633 (MIC 9.38 ug/ml), and fungi C. albicans ATCC 2002 (MIC 18.75 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
18.75 µg/mL

Target

Candida albicans ATCC 2002

Source & Reference

dbAMP DRAMP

Other

), S. aureus ATCC 2592 (MIC 4.7 ug/ml), B. subtilis ATCC 6633 (MIC 9.38 ug/ml), and fungi C. albicans ATCC 2002 (MIC 18.75 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
>200 µg/mL

Target

E.coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E.coli ATCC 25922 (MIC >200 ug/ml), B. dysenteriae (MIC 35 ug/ml), S. aureus ATCC 2592 (MIC 4.7 ug/ml), B. subtilis ATCC 663
Evidence 7 Activity

Activity

MIC
Antifungal
35 µg/mL

Target

B. dysenteriae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E.coli ATCC 25922 (MIC >200 ug/ml), B. dysenteriae (MIC 35 ug/ml), S. aureus ATCC 2592 (MIC 4.7 ug/ml), B. subtilis ATCC 6633 (MIC 9.38 ug/ml), and fungi C
Evidence 8 Activity

Activity

MIC
Antifungal
4.7 µg/mL

Target

Staphylococcus aureus ATCC 2592

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E.coli ATCC 25922 (MIC >200 ug/ml), B. dysenteriae (MIC 35 ug/ml), S. aureus ATCC 2592 (MIC 4.7 ug/ml), B. subtilis ATCC 6633 (MIC 9.38 ug/ml), and fungi C. albicans ATCC 2002 (MIC 18.75 ug/ml
Evidence 9 Activity

Activity

MIC
Antifungal
9.38 µg/mL

Target

B. subtilis ATCC 6633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

922 (MIC >200 ug/ml), B. dysenteriae (MIC 35 ug/ml), S. aureus ATCC 2592 (MIC 4.7 ug/ml), B. subtilis ATCC 6633 (MIC 9.38 ug/ml), and fungi C. albicans ATCC 2002 (MIC 18.75 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
18.75 µg/mL

Target

Candida albicans ATCC 2002

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

), S. aureus ATCC 2592 (MIC 4.7 ug/ml), B. subtilis ATCC 6633 (MIC 9.38 ug/ml), and fungi C. albicans ATCC 2002 (MIC 18.75 ug/ml).
Evidence 11 Activity

Activity

1% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 25 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis. | Amino Acids | 2013
Evidence 12 Activity

Activity

5% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 50 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis. | Amino Acids | 2013
Evidence 13 Activity

Activity

6% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
6% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide diversity in the skin of the torrent frog, Amolops jingdongensis. | Amino Acids | 2013
Evidence 14 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.22828809] It exhibits hemolysis of 1.32%, 5.37%, 6.35%, 16.55% at 25 µg/ml, 50 µg/ml, 100 µg/ml, 200 µg/ml against rabbit red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids 44:481-487(2013)