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Peptide record

TPDB08607

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08607
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FLPAALAGIGGILGKLF
Physicochemical Analysis
C82H132N18O18
RNDCEQHMSTWYV
GL
1658.06
10.10
1
0
11
+1
-4.15
1.653
155.29
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
3
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
2
I
4
L
1
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 2 L: 4 K: 1 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C82H132N18O18
1658.06
10.10
+1
-4.15
1.653
Evidence Records 39 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

Escherichia coli ATCC 35218

Source & Reference

dbAMP

Other

Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM),
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli ML-35p

Source & Reference

dbAMP

Other

Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (M
Evidence 4 Activity

Activity

MIC
Antibacterial
>200 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM
Evidence 5 Activity

Activity

MIC
Antibacterial
100 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP

Other

E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM), Gram+ S. aureus ATCC 25923, S. aureus ATCC 43300 (MRSA), S
Evidence 6 Activity

Activity

MIC
Antibacterial
>200 µM

Target

S. enteritidis

Source & Reference

dbAMP

Other

sa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM), Gram+ S. aureus ATCC 25923, S. aureus ATCC 43300 (MRSA), S. aureus ATCC BAA-44, S. aureu
Evidence 7 Activity

Activity

MIC
Antibacterial
100 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP

Other

), S. aureus ATCC BAA-44, S. aureus ST1065 (all 6.25 uM), B. megaterium (1.56 uM), yeasts C. albicans ATCC 90028 (MIC 100 uM), C.parapsilosis ATCC 22019 (MIC >200 uM), and S. cerevisiae (25 uM). Active against paras
Evidence 8 Activity

Activity

MIC
Antibacterial
>200 µM

Target

C.parapsilosis ATCC 22019

Source & Reference

dbAMP

Other

T1065 (all 6.25 uM), B. megaterium (1.56 uM), yeasts C. albicans ATCC 90028 (MIC 100 uM), C.parapsilosis ATCC 22019 (MIC >200 uM), and S. cerevisiae (25 uM). Active against parasites L. infantum, L. major, L. tropica, L
Evidence 9 Activity

Activity

IC50
Antibacterial
6.7-23.5 µM

Target

T. cruzi

Source & Reference

dbAMP

Other

, L. infantum amastigotes Axenic, L. infantum amastigotes Intramacrophagic, T. brucei,and T. cruzi (IC50 6.7-23.5 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC
Evidence 11 Activity

Activity

MIC
Antifungal
50 µM

Target

Escherichia coli ATCC 35218

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM),
Evidence 12 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli ML-35p

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (M
Evidence 13 Activity

Activity

MIC
Antifungal
>200 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM
Evidence 14 Activity

Activity

MIC
Antifungal
100 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP CAFPdb Antifungipept

Other

E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM), Gram+ S. aureus ATCC 25923, S. aureus ATCC 43300 (MRSA), S
Evidence 15 Activity

Activity

MIC
Antifungal
>200 µM

Target

S. enteritidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

sa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM), Gram+ S. aureus ATCC 25923, S. aureus ATCC 43300 (MRSA), S. aureus ATCC BAA-44, S. aureu
Evidence 16 Activity

Activity

MIC
Antifungal
100 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP CAFPdb Antifungipept

Other

), S. aureus ATCC BAA-44, S. aureus ST1065 (all 6.25 uM), B. megaterium (1.56 uM), yeasts C. albicans ATCC 90028 (MIC 100 uM), C.parapsilosis ATCC 22019 (MIC >200 uM), and S. cerevisiae (25 uM). Active against paras
Evidence 17 Activity

Activity

MIC
Antifungal
>200 µM

Target

C.parapsilosis ATCC 22019

Source & Reference

dbAMP CAFPdb Antifungipept

Other

T1065 (all 6.25 uM), B. megaterium (1.56 uM), yeasts C. albicans ATCC 90028 (MIC 100 uM), C.parapsilosis ATCC 22019 (MIC >200 uM), and S. cerevisiae (25 uM). Active against parasites L. infantum, L. major, L. tropica, L
Evidence 18 Activity

Activity

IC50
Antifungal
6.7-23.5 µM

Target

T. cruzi

Source & Reference

dbAMP CAFPdb Antifungipept

Other

, L. infantum amastigotes Axenic, L. infantum amastigotes Intramacrophagic, T. brucei,and T. cruzi (IC50 6.7-23.5 uM).
Evidence 19 Activity

Activity

MIC
Antiparasitic
5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC
Evidence 20 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Escherichia coli ATCC 35218

Source & Reference

dbAMP 3.0

Other

Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM),
Evidence 21 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Escherichia coli ML-35p

Source & Reference

dbAMP 3.0

Other

Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (M
Evidence 22 Activity

Activity

MIC
Antiparasitic
>200 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0

Other

. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM
Evidence 23 Activity

Activity

MIC
Antiparasitic
100 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP 3.0

Other

E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM), Gram+ S. aureus ATCC 25923, S. aureus ATCC 43300 (MRSA), S
Evidence 24 Activity

Activity

MIC
Antiparasitic
>200 µM

Target

S. enteritidis

Source & Reference

dbAMP 3.0

Other

sa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM), Gram+ S. aureus ATCC 25923, S. aureus ATCC 43300 (MRSA), S. aureus ATCC BAA-44, S. aureu
Evidence 25 Activity

Activity

MIC
Antiparasitic
100 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP 3.0

Other

), S. aureus ATCC BAA-44, S. aureus ST1065 (all 6.25 uM), B. megaterium (1.56 uM), yeasts C. albicans ATCC 90028 (MIC 100 uM), C.parapsilosis ATCC 22019 (MIC >200 uM), and S. cerevisiae (25 uM). Active against paras
Evidence 26 Activity

Activity

MIC
Antiparasitic
>200 µM

Target

C.parapsilosis ATCC 22019

Source & Reference

dbAMP 3.0

Other

T1065 (all 6.25 uM), B. megaterium (1.56 uM), yeasts C. albicans ATCC 90028 (MIC 100 uM), C.parapsilosis ATCC 22019 (MIC >200 uM), and S. cerevisiae (25 uM). Active against parasites L. infantum, L. major, L. tropica, L
Evidence 27 Activity

Activity

IC50
Antiparasitic
6.7-23.5 µM

Target

T. cruzi

Source & Reference

dbAMP 3.0

Other

, L. infantum amastigotes Axenic, L. infantum amastigotes Intramacrophagic, T. brucei,and T. cruzi (IC50 6.7-23.5 uM).
Evidence 28 Activity

Activity

MIC
Antiviral
5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC
Evidence 29 Activity

Activity

MIC
Antiviral
50 µM

Target

Escherichia coli ATCC 35218

Source & Reference

dbAMP 3.0

Other

Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM),
Evidence 30 Activity

Activity

MIC
Antiviral
25 µM

Target

Escherichia coli ML-35p

Source & Reference

dbAMP 3.0

Other

Active against E. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (M
Evidence 31 Activity

Activity

MIC
Antiviral
>200 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0

Other

. coli ATCC 25922 (MIC 5 uM), E. coli ATCC 35218 (MIC 50 uM), E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM
Evidence 32 Activity

Activity

MIC
Antiviral
100 µM

Target

Klebsiella pneumoniae ATCC 13883

Source & Reference

dbAMP 3.0

Other

E. coli ML-35p (MIC 25 uM), P.aeruginosa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM), Gram+ S. aureus ATCC 25923, S. aureus ATCC 43300 (MRSA), S
Evidence 33 Activity

Activity

MIC
Antiviral
>200 µM

Target

S. enteritidis

Source & Reference

dbAMP 3.0

Other

sa ATCC 27853 (MIC >200 uM), A. baumannii (25 uM), K. pneumoniae ATCC 13883 (MIC 100 uM), S. enteritidis (MIC >200 uM), Gram+ S. aureus ATCC 25923, S. aureus ATCC 43300 (MRSA), S. aureus ATCC BAA-44, S. aureu
Evidence 34 Activity

Activity

MIC
Antiviral
100 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP 3.0

Other

), S. aureus ATCC BAA-44, S. aureus ST1065 (all 6.25 uM), B. megaterium (1.56 uM), yeasts C. albicans ATCC 90028 (MIC 100 uM), C.parapsilosis ATCC 22019 (MIC >200 uM), and S. cerevisiae (25 uM). Active against paras
Evidence 35 Activity

Activity

MIC
Antiviral
>200 µM

Target

C.parapsilosis ATCC 22019

Source & Reference

dbAMP 3.0

Other

T1065 (all 6.25 uM), B. megaterium (1.56 uM), yeasts C. albicans ATCC 90028 (MIC 100 uM), C.parapsilosis ATCC 22019 (MIC >200 uM), and S. cerevisiae (25 uM). Active against parasites L. infantum, L. major, L. tropica, L
Evidence 36 Activity

Activity

IC50
Antiviral
6.7-23.5 µM

Target

T. cruzi

Source & Reference

dbAMP 3.0

Other

, L. infantum amastigotes Axenic, L. infantum amastigotes Intramacrophagic, T. brucei,and T. cruzi (IC50 6.7-23.5 uM).
Evidence 37 Activity

Activity

50% Hemolysis
Toxicity
44 µM
Hemolytic Cytotoxic
50% Hemolysis | 44 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial and leishmanicidal activities of temporin-SHd, a 17-residue long membrane-damaging peptide. | Biochimie | 2013
Evidence 38 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochimie. 2013 Feb 95(2):388-99.
Evidence 39 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.