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Peptide record

TPDB08602

Antibacterial Antiviral Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08602
Antibacterial Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antiviral, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, AI4AVP, and other sources, with an available 3D structural model.
Sequence
SLSRFLRFLKIVYRRAF
Physicochemical Analysis
C104H166N30O21
NDCEQGHMPTW
R
2172.65
12.41
5
0
10
+5
-1.93
0.324
114.71
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1490
68.58
3
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
1
K
0
M
3
F
0
P
2
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 1 M: 0 F: 3 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
17
C104H166N30O21
2172.65
12.41
+5
-1.93
0.324
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus aureus USA300 MRSA

Source & Reference

NA

Other

active against S. aureus USA300 MRSA (MIC 12.5 uM) and E. coli (MIC 25 uM). inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 0.83 u
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli

Source & Reference

NA

Other

active against S. aureus USA300 MRSA (MIC 12.5 uM) and E. coli (MIC 25 uM). inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 0.83 uM).
Evidence 3 Activity

Activity

MIC
Antiviral
12.5 µM

Target

Staphylococcus aureus USA300 MRSA

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
active against S. aureus USA300 MRSA (MIC 12.5 uM) and E. coli (MIC 25 uM). inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 0.83 u
Evidence 4 Activity

Activity

MIC
Antiviral
25 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

active against S. aureus USA300 MRSA (MIC 12.5 uM) and E. coli (MIC 25 uM). inhibited Human Immunodeficiency Virus Type 1 HIV-1 (EC50 0.83 uM).
Evidence 5 Activity

Activity

50% Cell death
Toxicity
8.6 µM
Cytotoxic
50% Cell death | 8.6 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database. | Antimicrob Agents Chemother | 2010