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Peptide record

TPDB08601

Antibacterial Anticancer Antiviral Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08601
Antibacterial Anticancer Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AI4AVP dbAMP 3.0 DRAVP 2.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AI4AVP, and other sources, with an available 3D structural model.
Sequence
LFRLIKSLIKRLVSAFK
Physicochemical Analysis
C98H170N26O20
NDCEQGHMPTWY
L
2032.59
12.43
5
0
10
+5
-0.37
0.794
160.59
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
4
L
3
K
0
M
2
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 3 M: 0 F: 2 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C98H170N26O20
2032.59
12.43
+5
-0.37
0.794
Evidence Records 13 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Escherichia coli AB94012

Source & Reference

NA

Other

Mucroporin-M1 is active against E. coli AB94012 (MIC 12.5 ug/ml), P. aeruginosa AB93066 (MIC 100 ug/ml), B. thuringiensis AB92037 (MIC 25 ug/ml), B. subti
Evidence 2 Activity

Activity

MIC
Antibacterial
100 µg/mL

Target

Pseudomonas aeruginosa AB93066

Source & Reference

NA

Other

Mucroporin-M1 is active against E. coli AB94012 (MIC 12.5 ug/ml), P. aeruginosa AB93066 (MIC 100 ug/ml), B. thuringiensis AB92037 (MIC 25 ug/ml), B. subtilis AB91021 (MIC 25 ug/ml), S. aureus A
Evidence 3 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

B. thuringiensis AB92037

Source & Reference

NA

Other

s active against E. coli AB94012 (MIC 12.5 ug/ml), P. aeruginosa AB93066 (MIC 100 ug/ml), B. thuringiensis AB92037 (MIC 25 ug/ml), B. subtilis AB91021 (MIC 25 ug/ml), S. aureus AB94004 (MIC 5 ug/ml), clincal stain 1538
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

B. subtilis AB91021

Source & Reference

NA

Other

5 ug/ml), P. aeruginosa AB93066 (MIC 100 ug/ml), B. thuringiensis AB92037 (MIC 25 ug/ml), B. subtilis AB91021 (MIC 25 ug/ml), S. aureus AB94004 (MIC 5 ug/ml), clincal stain 1538 (MRCNS) (5 ug/ml) as well as HIV-1.
Evidence 5 Activity

Activity

MIC
Antibacterial
5 µg/mL

Target

Staphylococcus aureus AB94004

Source & Reference

NA

Other

100 ug/ml), B. thuringiensis AB92037 (MIC 25 ug/ml), B. subtilis AB91021 (MIC 25 ug/ml), S. aureus AB94004 (MIC 5 ug/ml), clincal stain 1538 (MRCNS) (5 ug/ml) as well as HIV-1. Also active against measles McV (
Evidence 6 Activity

Activity

MIC
Antiviral
12.5 µg/mL

Target

Escherichia coli AB94012

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Mucroporin-M1 is active against E. coli AB94012 (MIC 12.5 ug/ml), P. aeruginosa AB93066 (MIC 100 ug/ml), B. thuringiensis AB92037 (MIC 25 ug/ml), B. subti
Evidence 7 Activity

Activity

MIC
Antiviral
100 µg/mL

Target

Pseudomonas aeruginosa AB93066

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

Mucroporin-M1 is active against E. coli AB94012 (MIC 12.5 ug/ml), P. aeruginosa AB93066 (MIC 100 ug/ml), B. thuringiensis AB92037 (MIC 25 ug/ml), B. subtilis AB91021 (MIC 25 ug/ml), S. aureus A
Evidence 8 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

B. thuringiensis AB92037

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

s active against E. coli AB94012 (MIC 12.5 ug/ml), P. aeruginosa AB93066 (MIC 100 ug/ml), B. thuringiensis AB92037 (MIC 25 ug/ml), B. subtilis AB91021 (MIC 25 ug/ml), S. aureus AB94004 (MIC 5 ug/ml), clincal stain 1538
Evidence 9 Activity

Activity

MIC
Antiviral
25 µg/mL

Target

B. subtilis AB91021

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

5 ug/ml), P. aeruginosa AB93066 (MIC 100 ug/ml), B. thuringiensis AB92037 (MIC 25 ug/ml), B. subtilis AB91021 (MIC 25 ug/ml), S. aureus AB94004 (MIC 5 ug/ml), clincal stain 1538 (MRCNS) (5 ug/ml) as well as HIV-1.
Evidence 10 Activity

Activity

MIC
Antiviral
5 µg/mL

Target

Staphylococcus aureus AB94004

Source & Reference

dbAMP 3.0 DRAVP 2.0

Other

100 ug/ml), B. thuringiensis AB92037 (MIC 25 ug/ml), B. subtilis AB91021 (MIC 25 ug/ml), S. aureus AB94004 (MIC 5 ug/ml), clincal stain 1538 (MRCNS) (5 ug/ml) as well as HIV-1. Also active against measles McV (
Evidence 11 Activity

Activity

50% Cytotoxicity
Toxicity
70.46 µg/mL
Cytotoxic
50% Cytotoxicity | 70.46 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Virucidal Activity of a Scorpion Venom Peptide Variant mucroporin-M1 Against Measles, SARS-CoV and Influenza H5N1 Viruses. | Peptides | 2011
Evidence 12 Activity

Activity

50% Cytotoxicity
Toxicity
83.35 µg/mL
Cytotoxic
50% Cytotoxicity | 83.35 | µg/mL | target cell: Madin-Darby canine kidney cells

Target

Madin-Darby canine kidney cells

Source & Reference

NA
DBAASP
Virucidal Activity of a Scorpion Venom Peptide Variant mucroporin-M1 Against Measles, SARS-CoV and Influenza H5N1 Viruses. | Peptides | 2011
Evidence 13 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.21620914]Vero cells:CC50=70.46µg/ ml(34.70µM) ##HeLa-ACE2 cells:CC50=61.58 µg/ml (30.31 µM) ##MDCK cells:CC50=83.35 µg/ml (41.03 µM).

Source & Reference

NA
DRAMP
Peptides. 2011 Jul 32(7):1518-25.