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Peptide record

TPDB08597

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08597
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
IIGPVLGLVGKALGGLL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C76H136N18O18
RNDCEQHMFSTWY
GL
1590.03
10.10
1
0
10
+1
-2.56
1.806
200.59
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
5
G
0
H
2
I
5
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 2 L: 5 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
17 reviewed residue count
C76H136N18O18 sequence-only estimate (linear, free termini)
1590.03 sequence-only estimate (linear, free termini)
10.10 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-2.56 sequence-only estimate (linear, free termini)
1.806 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
160 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Weakly active against C. albicans (MIC 160 uM). It also inhibited human hepatoma cell lines (Hep G2, SK-HEP-1 and Huh7) with IC50 values
Evidence 2 Activity

Activity

MIC
Antifungal
160 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Weakly active against C. albicans (MIC 160 uM). It also inhibited human hepatoma cell lines (Hep G2, SK-HEP-1 and Huh7) with IC50 values
Evidence 3 Activity

Activity

42.03% Hemolysis
Toxicity
40.3 µM
Hemolytic Cytotoxic
42.03% Hemolysis | 40.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular characterization and bioactivity evaluation of two novel bombinin peptides from the skin secretion of Oriental fire-bellied toad, Bombina orientalis. | Amino Acids | 2017
Evidence 4 Activity

Activity

100% Hemolysis
Toxicity
161.1 µM
Hemolytic Cytotoxic
100% Hemolysis | 161.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular characterization and bioactivity evaluation of two novel bombinin peptides from the skin secretion of Oriental fire-bellied toad, Bombina orientalis. | Amino Acids | 2017
Evidence 5 Activity

Activity

% Hemolysis
Toxicity
42.03 %
Hemolytic Cytotoxic
Hemolytic_activity: Human Red cells: caused 42.03% hemolysis of the red cells at a concentration of 40.3 µM while reaching 100% hemolysis at 161.1 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2018 Feb 50(2):241-253
Evidence 6 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.