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Peptide record

TPDB08597

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08597
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP AFP-GFuse Antifungipept CAFPdb dbAMP APD_complete PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
IIGPVLGLVGKALGGLL
Physicochemical Analysis
C76H136N18O18
RNDCEQHMFSTWY
GL
1590.03
10.10
1
0
10
+1
-1.96
1.806
200.59
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
5
G
0
H
2
I
5
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 2 L: 5 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
17
C76H136N18O18
1590.03
10.10
+1
-1.96
1.806
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
160 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Weakly active against C. albicans (MIC 160 uM). It also inhibited human hepatoma cell lines (Hep G2, SK-HEP-1 and Huh7) with IC50 values
Evidence 2 Activity

Activity

MIC
Antifungal
160 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Weakly active against C. albicans (MIC 160 uM). It also inhibited human hepatoma cell lines (Hep G2, SK-HEP-1 and Huh7) with IC50 values
Evidence 3 Activity

Activity

42.03% Hemolysis
Toxicity
40.3 µM
Hemolytic Cytotoxic
42.03% Hemolysis | 40.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular characterization and bioactivity evaluation of two novel bombinin peptides from the skin secretion of Oriental fire-bellied toad, Bombina orientalis. | Amino Acids | 2017
Evidence 4 Activity

Activity

100% Hemolysis
Toxicity
161.1 µM
Hemolytic Cytotoxic
100% Hemolysis | 161.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Molecular characterization and bioactivity evaluation of two novel bombinin peptides from the skin secretion of Oriental fire-bellied toad, Bombina orientalis. | Amino Acids | 2017
Evidence 5 Activity

Activity

% Hemolysis
Toxicity
42.03 %
Hemolytic Cytotoxic
Hemolytic_activity: Human Red cells: caused 42.03% hemolysis of the red cells at a concentration of 40.3 µM while reaching 100% hemolysis at 161.1 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2018 Feb 50(2):241-253
Evidence 6 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.