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Peptide record

TPDB08595

Antibacterial Antifungal Hemolysis Toxicity standard

17 amino acids

3D PDB MODEL

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TPDB ID TPDB08595

Activity

Antibacterial Antifungal Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP APD_complete APD_hemolytic PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.

Sequence

GFVALLKKLPLILKHLP

FASTA

>TPDB08595|Antibacterial;Antifungal;Hemolysis;Toxicity|length=17
GFVALLKKLPLILKHLP

Formula C95H162N22O18

Absent Amino Acids RNDCEQMSTWY

Common Amino Acids L

Mass 1900.47

PI 10.84

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +3

Boman Index -0.06

Hydrophobicity 1.035

Aliphatic Index 183.53

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 6 K: 3 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

Formula

C95H162N22O18

Mass

1900.47

10.84

Net Charge

Boman Index

-0.06

Hydrophobicity

1.035

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µM

Target

Target Organism Escherichia coli NBRC 14237

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 3.1 uM), M. luteus NBRC 12708 (MIC 6.2 uM), and S. cerevisiae

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.1 µM

Target

Target Organism Staphylococcus aureus NBRC 12732

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 3.1 uM), M. luteus NBRC 12708 (MIC 6.2 uM), and S. cerevisiae NBRC 10217 (MIC 25 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.2 µM

Target

Target Organism M. luteus NBRC 12708

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 3.1 uM), M. luteus NBRC 12708 (MIC 6.2 uM), and S. cerevisiae NBRC 10217 (MIC 25 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism S. cerevisiae NBRC 10217

Source & Reference

Database Source dbAMP

Other

Evidence Text

7 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 3.1 uM), M. luteus NBRC 12708 (MIC 6.2 uM), and S. cerevisiae NBRC 10217 (MIC 25 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µM

Target

Target Organism Escherichia coli NBRC 14237

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 3.1 uM), M. luteus NBRC 12708 (MIC 6.2 uM), and S. cerevisiae

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.1 µM

Target

Target Organism Staphylococcus aureus NBRC 12732

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 3.1 uM), M. luteus NBRC 12708 (MIC 6.2 uM), and S. cerevisiae NBRC 10217 (MIC 25 uM).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 6.2 µM

Target

Target Organism M. luteus NBRC 12708

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 3.1 uM), M. luteus NBRC 12708 (MIC 6.2 uM), and S. cerevisiae NBRC 10217 (MIC 25 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism S. cerevisiae NBRC 10217

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

7 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 3.1 uM), M. luteus NBRC 12708 (MIC 6.2 uM), and S. cerevisiae NBRC 10217 (MIC 25 uM).

Evidence 9 Activity

Activity

Activity Endpoint (23.5±1.3)% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

(23.5±1.3)% Hemolysis | 100 | µM | target cell: Rat erythrocytes

Target

Target Cell Rat erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Isolation of biologically active peptides from the venom of Japanese carpenter bee, Xylocopa appendiculata. | J Venom Anim Toxins Incl Trop Dis | 2017

Evidence 10 Hemolysis

Source & Reference

source APD_complete APD_hemolytic PD_Hemolysis

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.