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Peptide record

TPDB08592

Antibacterial Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08592
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, and Peptipedia, with an available 3D structural model.
Sequence
FLGGLIKWKWPWWPWRR
Physicochemical Analysis
C120H162N30O18
ANDCEQHMSTYV
W
2312.80
12.42
4
0
9
+4
-7.29
-0.612
68.82
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
27500
1189.04
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
2
L
2
K
0
M
1
F
2
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 2 M: 0 F: 1 P: 2 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
17
C120H162N30O18
2312.80
12.42
+4
-7.29
-0.612
Evidence Records 4 records
Evidence 1 Activity

Activity

90% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
90% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 2 Activity

Activity

5.9% Hemolysis
Toxicity
15.62 µg/mL
Hemolytic Cytotoxic
5.9% Hemolysis | 15.62 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015
Evidence 4 Activity

Activity

50% Cell death
Toxicity
125 µg/mL
Cytotoxic
50% Cell death | 125 | µg/mL | target cell: Human lung normal epithelial cells NL20

Target

Human lung normal epithelial cells NL20

Source & Reference

NA
DBAASP
Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae | PLoS One | 2015