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Peptide record

TPDB08569

Antibacterial Antifungal Antiviral Toxicity standard

17 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB08569

Activity

Antibacterial Antifungal Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP AI4AVP AVPpred-BWR dbAMP 3.0 DRAVP 2.0 ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.

Sequence

APKAMRLLRRLLRRLLR

FASTA

>TPDB08569|Antibacterial;Antifungal;Antiviral;Toxicity|length=17
APKAMRLLRRLLRRLLR

Formula C94H178N36O18S1

Absent Amino Acids NDCEQGHIFSTWYV

Common Amino Acids RL

Mass 2132.74

PI 13.10

Basic Residues 7

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +7

Boman Index 2.37

Hydrophobicity -0.247

Aliphatic Index 149.41

Half Life

Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

Amino Acid Distribution

A: 2 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 1 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C94H178N36O18S1

Mass

2132.74

13.10

Net Charge

Boman Index

2.37

Hydrophobicity

-0.247

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

active against Gram- E. coli (MIC 2 ug/ml), P. putida (MIC 4 ug/ml), S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml),

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism P. putida

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against Gram- E. coli (MIC 2 ug/ml), P. putida (MIC 4 ug/ml), S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml),

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source dbAMP

Other

Evidence Text

active against Gram- E. coli (MIC 2 ug/ml), P. putida (MIC 4 ug/ml), S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP

Other

Evidence Text

Gram- E. coli (MIC 2 ug/ml), P. putida (MIC 4 ug/ml), S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Evidence Text

, P. putida (MIC 4 ug/ml), S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S. cerevisiae (MIC 2 ug/ml),

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism S. mutans

Source & Reference

Database Source dbAMP

Other

Evidence Text

, S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S. cerevisiae (MIC 2 ug/ml), and C. albicans (MIC 1 u

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP

Other

Evidence Text

Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S. cerevisiae (MIC 2 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP

Other

Evidence Text

ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S. cerevisiae (MIC 2 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP

Other

Evidence Text

mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S. cerevisiae (MIC 2 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

active against Gram- E. coli (MIC 2 ug/ml), P. putida (MIC 4 ug/ml), S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml),

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism P. putida

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against Gram- E. coli (MIC 2 ug/ml), P. putida (MIC 4 ug/ml), S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml),

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

active against Gram- E. coli (MIC 2 ug/ml), P. putida (MIC 4 ug/ml), S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µg/mL

Target

Target Organism S. mutans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S. cerevisiae (MIC 2 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S. cerevisiae (MIC 2 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S. cerevisiae (MIC 2 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Source Activity Label	Source Definition
Antiviral	dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

active against Gram- E. coli (MIC 2 ug/ml), P. putida (MIC 4 ug/ml), S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml),

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4 µg/mL

Target

Target Organism P. putida

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

active against Gram- E. coli (MIC 2 ug/ml), P. putida (MIC 4 ug/ml), S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml),

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

active against Gram- E. coli (MIC 2 ug/ml), P. putida (MIC 4 ug/ml), S. enteritidis (MIC 2 ug/ml), Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4 µg/mL

Target

Target Organism S. mutans

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism C. neoformans

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

Gram+ B. subtilis (MIC 2 ug/ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S. cerevisiae (MIC 2 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 2 µg/mL

Target

Target Organism S. cerevisiae

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

ml), S. aureus (MIC 2 ug/ml), S. mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S. cerevisiae (MIC 2 ug/ml), and C. albicans (MIC 1 ug/ml).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 1 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP 3.0 DRAVP 2.0

Other

Evidence Text

mutans (MIC 4 ug/ml), fungi C. neoformans (MIC 2 ug/ml), S. cerevisiae (MIC 2 ug/ml), and C. albicans (MIC 1 ug/ml).