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Peptide record

TPDB08566

Antibacterial Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08566
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia AFP-GFuse CAFPdb
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
FKRLKKLISWIKRKRQQ
Physicochemical Analysis
C105H182N34O21
ANDCEGHMPTYV
K
2256.82
12.72
8
0
6
+8
3.95
-1.312
91.76
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
243.71
3
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
2
L
5
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 2 K: 5 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C105H182N34O21
2256.82
12.72
+8
3.95
-1.312
Evidence Records 3 records
Evidence 1 Activity

Activity

1% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
1% Hemolysis | 250 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Novel chimeric peptide with enhanced cell specificity and anti-inflammatory activity. | Biochem Biophys Res Commun | 2015
Evidence 2 Activity

Activity

50% Cell death
Toxicity
357.5 µM
Cytotoxic
50% Cell death | 357.5 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Novel chimeric peptide with enhanced cell specificity and anti-inflammatory activity. | Biochem Biophys Res Commun | 2015
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26028561] HPA3NT3 and melittin revealed the hemolysis of 68.2% and 100% at 250 µM, respectively, but Hn-Mc was 1.1% at the same concentration | Cytotoxicity: [Ref.26028561] The IC50 of HPA3NT3, melittin and Hn-Mc against HaCaT cells were 49.5, 2.8 and 357.5 µM, respectively

Target

erythrocytes

Source & Reference

NA
DRAMP
Antibiotics (Basel). 2020 Jul 28 9(8):454. doi: 10.3390/antibiotics9080454.##Biochem Biophys Res Commun. 2015 Jul 31 463(3):322-8. doi: 10.1016/j.bbrc.2015.05.063. Epub 2015 May 29.