Back to search

Peptide record

TPDB08563

Antibacterial Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08563
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
FKAFRWAWRWKKLAAPS
Physicochemical Analysis
C107H153N29O19
NDCEQGHIMTYV
A
2149.57
12.43
5
0
10
+5
-3.88
-0.541
46.47
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
16500
767.59
1
Residue Composition
number
4
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
3
K
0
M
2
F
1
P
1
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 3 M: 0 F: 2 P: 1 S: 1 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
17
C107H153N29O19
2149.57
12.43
+5
-3.88
-0.541
Evidence Records 8 records
Evidence 1 Activity

Activity

2% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 512 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Killing of Staphylococcus aureus and Salmonella enteritidis and neutralization of lipopolysaccharide by 17-residue bovine lactoferricins: improved activity of Trp/Ala-containing molecules. | Sci Rep | 2017
Evidence 2 Activity

Activity

<2% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
<2% Hemolysis | 256 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Fatty acid modified-antimicrobial peptide analogues with potent antimicrobial activity and topical therapeutic efficacy against Staphylococcus hyicus. | Appl Microbiol Biotechnol | 2021
Evidence 3 Activity

Activity

23% Killing
Toxicity
256 µg/mL
Cytotoxic
23% Killing | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Fatty acid modified-antimicrobial peptide analogues with potent antimicrobial activity and topical therapeutic efficacy against Staphylococcus hyicus. | Appl Microbiol Biotechnol | 2021
Evidence 4 Activity

Activity

LC50
Toxicity
773.5 µg/mL
Cytotoxic
LC50 | 773.5 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Fatty acid modified-antimicrobial peptide analogues with potent antimicrobial activity and topical therapeutic efficacy against Staphylococcus hyicus. | Appl Microbiol Biotechnol | 2021
Evidence 5 Activity

Activity

87.09% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
87.09% Hemolysis | 256 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Fatty acid modified-antimicrobial peptide analogues with potent antimicrobial activity and topical therapeutic efficacy against Staphylococcus hyicus. | Appl Microbiol Biotechnol | 2021
Evidence 6 Activity

Activity

0% Killing
Toxicity
16 µg/mL
Cytotoxic
0% Killing | 16 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Fatty acid modified-antimicrobial peptide analogues with potent antimicrobial activity and topical therapeutic efficacy against Staphylococcus hyicus. | Appl Microbiol Biotechnol | 2021
Evidence 7 Activity

Activity

53.4% Killing
Toxicity
256 µg/mL
Cytotoxic
53.4% Killing | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Fatty acid modified-antimicrobial peptide analogues with potent antimicrobial activity and topical therapeutic efficacy against Staphylococcus hyicus. | Appl Microbiol Biotechnol | 2021
Evidence 8 Activity

Activity

LC50
Toxicity
111 µg/mL
Cytotoxic
LC50 | 111 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Fatty acid modified-antimicrobial peptide analogues with potent antimicrobial activity and topical therapeutic efficacy against Staphylococcus hyicus. | Appl Microbiol Biotechnol | 2021