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Peptide record

TPDB08549

Antibacterial Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08549
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KFWSLLKKALRLWANVL
Physicochemical Analysis
C103H164N26O20
DCEQGHIMPTY
L
2086.60
11.73
4
0
11
+4
-3.57
0.429
143.53
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
527.17
2
Residue Composition
number
2
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
5
L
3
K
0
M
1
F
0
P
1
S
0
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 5 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 2 Y: 0 V: 1
Chemical Descriptors
17
C103H164N26O20
2086.60
11.73
+4
-3.57
0.429
Evidence Records 2 records
Evidence 1 Activity

Activity

70% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
70% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel Antimicrobial Peptide CPF-C1 Analogs with Superior Stabilities and Activities against Multidrug-Resistant Bacteria. | Chem Biol Drug Des | 2017
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.28371431] 0% hemolysis at 0 µg/ml , 5% hemolysis at 4 µg/ml , 8% hemolysis at 8 µg/ml , 20% hemolysis at 16 µg/ml , 35% hemolysis at 32 µg/ml , 58% hemolysis at 64 µg/ml , 70% hemolysis at 128 µg/ml , 78% hemolysis at 256 µg/ml , 80% hemolysis at 512 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2017 Nov 90(5):690-702. doi: 10.1111/cbdd.12988.