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Peptide record

TPDB08534

Antibacterial Anticancer Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08534
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 17-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GKEFKRIVGRIYRLCCR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C92H157N31O21S2
ANDQHMPSTW
R
2097.57
10.69
6
1
6
+5
3.03
-0.388
85.88
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1615
0.77
3
Residue Composition
number
0
A
4
R
0
N
0
D
2
C
1
E
0
Q
2
G
0
H
2
I
1
L
2
K
0
M
1
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 2 E: 1 Q: 0 G: 2 H: 0 I: 2 L: 1 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
17 reviewed residue count
C92H157N31O21S2 sequence-only estimate (linear, free termini)
2097.57 sequence-only estimate (linear, free termini)
10.69 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
3.03 sequence-only estimate (linear, free termini)
-0.388 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
5% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of bactericidal efficiency, cell selectivity, and mechanism of short interspecific hybrid peptides. | Amino Acids | 2018
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 5%Hemolysis>128 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2018 Apr 50(3-4):453-468.