Back to search

Peptide record

TPDB08529

Antibacterial Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08529
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
GFKRIVQKIRDFLRNLV
Physicochemical Analysis
C97H164N30O22
ACEHMPSTWY
R
2102.56
12.13
5
1
8
+4
2.79
-0.094
125.88
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
0
E
1
Q
1
G
0
H
2
I
2
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 2 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
17
C97H164N30O22
2102.56
12.13
+4
2.79
-0.094
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
<35 µM
Hemolytic Cytotoxic
50% Hemolysis | <35 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probes. | Biochim Biophys Acta | 2017
Evidence 2 Activity

Activity

50% Cell death
Toxicity
40 µM
Cytotoxic
50% Cell death | 40 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probes. | Biochim Biophys Acta | 2017
Evidence 3 Activity

Activity

50% Cell death
Toxicity
13 µM
Cytotoxic
50% Cell death | 13 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Arginine-lysine positional swap of the LL-37 peptides reveals evolutional advantages of the native sequence and leads to bacterial probes. | Biochim Biophys Acta | 2017
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis