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Peptide record

TPDB08501

Antibacterial Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08501
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWAFRVCYRGICYRRAR
Physicochemical Analysis
C99H154N34O20S2
NDEQHLMPST
R
2204.65
11.23
6
0
8
+6
-0.87
-0.600
51.76
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
8605
390.31
4
Residue Composition
number
2
A
5
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
1
I
0
L
1
K
0
M
1
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 2 R: 5 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 1 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
17
C99H154N34O20S2
2204.65
11.23
+6
-0.87
-0.600
Evidence Records 3 records
Evidence 1 Activity

Activity

<=10% Hemolysis
Toxicity
40 µg/mL
Hemolytic Cytotoxic
<=10% Hemolysis | 40 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. | ACS Infect Dis | 2017
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Structure-Activity and -Toxicity Relationships of the Antimicrobial Peptide Tachyplesin-1. | ACS Infect Dis | 2017
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.28960954] MHC10=40 µg/ml against human red blood cells | Cytotoxicity: [Ref.28960954] The peptide did not show cytotoxicity against HEK293 cells at the highest tested concentration, 100 µg/ml.

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Infect Dis. 2017 Dec 8 3(12):917-926. doi: 10.1021/acsinfecdis.7b00123.