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Peptide record

TPDB08480

Antibacterial Antifungal Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08480
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
VKWRWKWKWRWKWKWKV
Physicochemical Analysis
C135H186N36O18
ANDCEQGHILMFPSTY
W
2601.19
12.46
8
0
9
+8
-5.25
-1.782
34.12
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
38500
1480.09
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
6
K
0
M
0
F
0
P
0
S
0
T
7
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 7 Y: 0 V: 2
Chemical Descriptors
17
C135H186N36O18
2601.19
12.46
+8
-5.25
-1.782
Evidence Records 4 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
62.8±5.8 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 62.8±5.8 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>320 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016
Evidence 3 Activity

Activity

31% Hemolysis
Toxicity
320 µg/mL
Hemolytic Cytotoxic
31% Hemolysis | 320 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A Designed Tryptophan- and Lysine/Arginine-Rich Antimicrobial Peptide with Therapeutic Potential for Clinical Antibiotic-Resistant Candida albicans Vaginitis. | J Med Chem | 2016
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis