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Peptide record

TPDB08456

Antibacterial Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08456
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KFLKKAKKFGKAFVKIL
Physicochemical Analysis
C100H168N24O18
RNDCEQHMPSTWY
K
1994.58
11.29
7
0
9
+7
1.85
0.035
97.65
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
2
L
7
K
0
M
3
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 2 K: 7 M: 0 F: 3 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C100H168N24O18
1994.58
11.29
+7
1.85
0.035
Evidence Records 6 records
Evidence 1 Activity

Activity

1% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
1% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A 17-mer Membrane-Active MSI-78 Derivative with Improved Selectivity toward Bacterial Cells. | Mol Pharm | 2015
Evidence 2 Activity

Activity

2% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A 17-mer Membrane-Active MSI-78 Derivative with Improved Selectivity toward Bacterial Cells. | Mol Pharm | 2015
Evidence 3 Activity

Activity

4% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
4% Hemolysis | 512 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A 17-mer Membrane-Active MSI-78 Derivative with Improved Selectivity toward Bacterial Cells. | Mol Pharm | 2015
Evidence 4 Activity

Activity

0% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
0% Hemolysis | 16 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Directed chemical dimerisation enhances the antibacterial activity of the antimicrobial peptide MSI-78(4–20) | Aust J Chem | 2023
Evidence 5 Activity

Activity

28% Killing
Toxicity
15.6 µg/mL
Cytotoxic
28% Killing | 15.6 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens. | Eur J Med Chem | 2022
Evidence 6 Activity

Activity

47% Killing
Toxicity
31.25 µg/mL
Cytotoxic
47% Killing | 31.25 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens. | Eur J Med Chem | 2022