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Peptide record

TPDB08455

Antibacterial Anticancer Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08455
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP CAFPdb dbAMP ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
IIGPVLGLIGKALGGLL
Physicochemical Analysis
C77H138N18O18
RNDCEQHMFSTWY
GL
1604.05
10.10
1
0
10
+1
-2.34
1.824
206.47
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
5
G
0
H
3
I
5
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 3 L: 5 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C77H138N18O18
1604.05
10.10
+1
-2.34
1.824
Evidence Records 3 records
Evidence 1 Activity

Activity

38% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
38% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of two Bombinin peptides with antimicrobial and anticancer activities from the skin secretion of Oriental Fire-bellied toad, Bombina orientalis | Chem Biol Drug Des | 2017
Evidence 2 Activity

Activity

85% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
85% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of two Bombinin peptides with antimicrobial and anticancer activities from the skin secretion of Oriental Fire-bellied toad, Bombina orientalis | Chem Biol Drug Des | 2017
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: Bombinin H-BO was found to lyse 38% of erythrocytes at concentration of 80.0 µm (128 mg/ml), and up to 85% at the concentration of 159.7 µm (256 mg/ml). | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2018 Jan 91(1):50-61.