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Peptide record

TPDB08455

Antibacterial Anticancer Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08455
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CancerPPD 2.0 dbACP CAFPdb dbAMP ToxinPred 3.0
standard
No
A 17-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CancerPPD 2.0, and other sources, with an available 3D structural model.
Sequence
IIGPVLGLIGKALGGLL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C77H138N18O18
RNDCEQHMFSTWY
GL
1604.05
10.10
1
0
10
+1
-2.61
1.824
206.47
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
5
G
0
H
3
I
5
L
1
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 3 L: 5 K: 1 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17 reviewed residue count
C77H138N18O18 sequence-only estimate (linear, free termini)
1604.05 sequence-only estimate (linear, free termini)
10.10 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-2.61 sequence-only estimate (linear, free termini)
1.824 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

38% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
38% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of two Bombinin peptides with antimicrobial and anticancer activities from the skin secretion of Oriental Fire-bellied toad, Bombina orientalis | Chem Biol Drug Des | 2017
Evidence 2 Activity

Activity

85% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
85% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Discovery of two Bombinin peptides with antimicrobial and anticancer activities from the skin secretion of Oriental Fire-bellied toad, Bombina orientalis | Chem Biol Drug Des | 2017
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: Bombinin H-BO was found to lyse 38% of erythrocytes at concentration of 80.0 µm (128 mg/ml), and up to 85% at the concentration of 159.7 µm (256 mg/ml). | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Chem Biol Drug Des. 2018 Jan 91(1):50-61.