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Peptide record

TPDB08451

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08451
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia dbACP AFP-GFuse Antifungipept CAFPdb dbAMP 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFSLIPKLVKGLISAFK
Physicochemical Analysis
C96H154N20O20
RNDCEQHMTWY
LKF
1908.40
10.84
3
0
10
+3
-2.10
1.147
137.65
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
3
L
3
K
0
M
3
F
1
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 3 K: 3 M: 0 F: 3 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C96H154N20O20
1908.40
10.84
+3
-2.10
1.147
Evidence Records 33 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.69 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli ATCC 25922 (MIC 4.69 uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. a
Evidence 2 Activity

Activity

MIC
Antibacterial
18.75 µM

Target

Enterobacter cloacae ATCC 13047

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli ATCC 25922 (MIC 4.69 uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epi
Evidence 3 Activity

Activity

MIC
Antibacterial
9.38 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

ive against Gram- E. coli ATCC 25922 (MIC 4.69 uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. f
Evidence 4 Activity

Activity

MIC
Antibacterial
2.34 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP DRAMP

Other

uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C.
Evidence 5 Activity

Activity

MIC
Antibacterial
1.17 µM

Target

Staphylococcus epidermidis ATCC 122225

Source & Reference

dbAMP DRAMP

Other

75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. kru
Evidence 6 Activity

Activity

MIC
Antibacterial
1.17 µM

Target

Enterococcus faecalis ATCC 4028

Source & Reference

dbAMP DRAMP

Other

uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. g
Evidence 7 Activity

Activity

MIC
Antibacterial
9.38 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP

Other

M), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhib
Evidence 8 Activity

Activity

MIC
Antibacterial
37.5 µM

Target

C. krusei ATCC 6258

Source & Reference

dbAMP DRAMP

Other

17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhibited parasite T. cruzi (MIC 2.5 uM)
Evidence 9 Activity

Activity

MIC
Antibacterial
17.75 µM

Target

C. glabrata ATCC 90030

Source & Reference

dbAMP DRAMP

Other

uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhibited parasite T. cruzi (MIC 2.5 uM), more effective than its parent peptide.
Evidence 10 Activity

Activity

MIC
Antibacterial
2.5 µM

Target

T. cruzi

Source & Reference

dbAMP DRAMP

Other

CC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhibited parasite T. cruzi (MIC 2.5 uM), more effective than its parent peptide.
Evidence 11 Activity

Activity

MIC
Antifungal
4.69 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against Gram- E. coli ATCC 25922 (MIC 4.69 uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. a
Evidence 12 Activity

Activity

MIC
Antifungal
18.75 µM

Target

Enterobacter cloacae ATCC 13047

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against Gram- E. coli ATCC 25922 (MIC 4.69 uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epi
Evidence 13 Activity

Activity

MIC
Antifungal
9.38 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ive against Gram- E. coli ATCC 25922 (MIC 4.69 uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. f
Evidence 14 Activity

Activity

MIC
Antifungal
2.34 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C.
Evidence 15 Activity

Activity

MIC
Antifungal
1.17 µM

Target

Staphylococcus epidermidis ATCC 122225

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. kru
Evidence 16 Activity

Activity

MIC
Antifungal
1.17 µM

Target

Enterococcus faecalis ATCC 4028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. g
Evidence 17 Activity

Activity

MIC
Antifungal
9.38 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhib
Evidence 18 Activity

Activity

MIC
Antifungal
37.5 µM

Target

C. krusei ATCC 6258

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhibited parasite T. cruzi (MIC 2.5 uM)
Evidence 19 Activity

Activity

MIC
Antifungal
17.75 µM

Target

C. glabrata ATCC 90030

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhibited parasite T. cruzi (MIC 2.5 uM), more effective than its parent peptide.
Evidence 20 Activity

Activity

MIC
Antifungal
2.5 µM

Target

T. cruzi

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

CC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhibited parasite T. cruzi (MIC 2.5 uM), more effective than its parent peptide.
Evidence 21 Activity

Activity

MIC
Antiparasitic
4.69 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
active against Gram- E. coli ATCC 25922 (MIC 4.69 uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. a
Evidence 22 Activity

Activity

MIC
Antiparasitic
18.75 µM

Target

Enterobacter cloacae ATCC 13047

Source & Reference

dbAMP 3.0 DRAMP

Other

active against Gram- E. coli ATCC 25922 (MIC 4.69 uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epi
Evidence 23 Activity

Activity

MIC
Antiparasitic
9.38 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0 DRAMP

Other

ive against Gram- E. coli ATCC 25922 (MIC 4.69 uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. f
Evidence 24 Activity

Activity

MIC
Antiparasitic
2.34 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP 3.0 DRAMP

Other

uM), E. cloacae ATCC 13047 (MIC 18.75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C.
Evidence 25 Activity

Activity

MIC
Antiparasitic
1.17 µM

Target

Staphylococcus epidermidis ATCC 122225

Source & Reference

dbAMP 3.0 DRAMP

Other

75 uM), P. aeruginosa ATCC 27853 (MIC 9.38 uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. kru
Evidence 26 Activity

Activity

MIC
Antiparasitic
1.17 µM

Target

Enterococcus faecalis ATCC 4028

Source & Reference

dbAMP 3.0 DRAMP

Other

uM), Gram+ S. aureus ATCC 29213 (MIC 2.34 uM), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. g
Evidence 27 Activity

Activity

MIC
Antiparasitic
9.38 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP 3.0 DRAMP

Other

M), S. epidermidis ATCC 122225 (MIC 1.17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhib
Evidence 28 Activity

Activity

MIC
Antiparasitic
37.5 µM

Target

C. krusei ATCC 6258

Source & Reference

dbAMP 3.0 DRAMP

Other

17 uM), E. faecalis ATCC 4028 (MIC 1.17 uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhibited parasite T. cruzi (MIC 2.5 uM)
Evidence 29 Activity

Activity

MIC
Antiparasitic
17.75 µM

Target

C. glabrata ATCC 90030

Source & Reference

dbAMP 3.0 DRAMP

Other

uM), yeasts C. albicans ATCC 90028 (MIC 9.38 uM), C. krusei ATCC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhibited parasite T. cruzi (MIC 2.5 uM), more effective than its parent peptide.
Evidence 30 Activity

Activity

MIC
Antiparasitic
2.5 µM

Target

T. cruzi

Source & Reference

dbAMP 3.0 DRAMP

Other

CC 6258 (MIC 37.5 uM), and C. glabrata ATCC 90030 (MIC 17.75 uM). Also inhibited parasite T. cruzi (MIC 2.5 uM), more effective than its parent peptide.
Evidence 31 Activity

Activity

IC50
Toxicity
14.01 µM
Cytotoxic
IC50 | 14.01 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Analogs of the Scorpion Venom Peptide Stigmurin: Structural Assessment, Toxicity, and Increased Antimicrobial Activity. | Toxins (Basel) | 2018
Evidence 32 Activity

Activity

40% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
40% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogs of the Scorpion Venom Peptide Stigmurin: Structural Assessment, Toxicity, and Increased Antimicrobial Activity. | Toxins (Basel) | 2018
Evidence 33 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29670004] Hemolysis 0% at 1.17 µM, hemolysis 2% at 2.34 µM, hemolysis 15% at 4.69 µM, hemolysis 27% at 9.38 µM, hemolysis 30% at 18.75 µM, hemolysis 30% at 37.50 µM, hemolysis 27% at 75.00 µM against human red blood cells | Cytotoxicity: [Ref.29670004] The cell viability of HeLa cell lines is 19%, 15%, 11%, 29%, 9%, 13% and 8% at peptide concentrations of 2, 4, 8, 10, 15, 20 and 40 µM. ##The cell viability of 3T3 cell lines is 81%, 73%, 69%, 61%, 51%, 20% and 15% at peptide concentrati

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxins (Basel). 2018 Apr 18 10(4). pii: E161.