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Peptide record

TPDB08445

BUF Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08445
BUF
Antibacterial Anticancer Antifungal Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RAGLQFPVGRVHRLLRK
Physicochemical Analysis
C90H155N33O19
NDCEIMSTWY
R
2003.43
12.88
6
0
7
+5
3.40
-0.388
108.82
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
1
Q
2
G
1
H
0
I
3
L
1
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 1 I: 0 L: 3 K: 1 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
17
C90H155N33O19
2003.43
12.88
+5
3.40
-0.388
Free
L
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 10 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Vero Cells And Hk-2 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Copper/zinc superoxide dismutase (SOD1)
In vitro
CCSSCCCGGGSSCSCC
Evidence 2 Activity

Activity

5.5±0.9% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
5.5±0.9% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
>300 µM
Hemolytic Cytotoxic
50% Hemolysis | >300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup. | Amino Acids | 2017
Evidence 4 Activity

Activity

IC50
Toxicity
>300 µM
Cytotoxic
IC50 | >300 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Comparative analysis of internalisation, haemolytic, cytotoxic and antibacterial effect of membrane-active cationic peptides: aspects of experimental setup. | Amino Acids | 2017
Evidence 5 Activity

Activity

8% Killing
Toxicity
128 µM
Cytotoxic
8% Killing | 128 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Hybrid peptide ATCUN-sh-Buforin: Influence of the ATCUN charge and stereochemistry on antimicrobial activity. | Biochimie | 2015
Evidence 6 Activity

Activity

0% Hemolysis
Toxicity
20 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 20 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The membrane action mechanism of analogs of the antimicrobial peptide Buforin 2. | Peptides | 2009
Evidence 7 Activity

Activity

2% Hemolysis
Toxicity
40 µg/mL
Hemolytic Cytotoxic
2% Hemolysis | 40 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The membrane action mechanism of analogs of the antimicrobial peptide Buforin 2. | Peptides | 2009
Evidence 8 Activity

Activity

5% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The membrane action mechanism of analogs of the antimicrobial peptide Buforin 2. | Peptides | 2009
Evidence 9 Activity

Activity

50% Hemolysis
Toxicity
400 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity and protease stability of peptides containing fluorinated amino acids | J Am Chem Soc | 2007
Evidence 10 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochimie. 2015 Jun 113:143-55.
Additional Detail Fields 1 fields
CCSSCCCGGGSSCSCC