Back to search

Peptide record

TPDB08444

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08444
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GFVALLKKLPLILKHLH
Physicochemical Analysis
C96H162N24O18
RNDCEQMSTWY
L
1940.49
10.84
5
0
10
+3
0.45
0.941
183.53
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
2
H
1
I
6
L
3
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 1 L: 6 K: 3 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C96H162N24O18
1940.49
10.84
+3
0.45
0.941
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Escherichia coli NBRC 14237

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC
Evidence 2 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

Staphylococcus aureus NBRC 12732

Source & Reference

dbAMP DRAMP

Other

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC 10217 (MIC 6.2 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

M. luteus NBRC 12708

Source & Reference

dbAMP DRAMP

Other

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC 10217 (MIC 6.2 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
6.2 µM

Target

S. cerevisiae NBRC 10217

Source & Reference

dbAMP DRAMP

Other

14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC 10217 (MIC 6.2 uM).
Evidence 5 Activity

Activity

MIC
Antifungal
3.1 µM

Target

Escherichia coli NBRC 14237

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC
Evidence 6 Activity

Activity

MIC
Antifungal
1.6 µM

Target

Staphylococcus aureus NBRC 12732

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC 10217 (MIC 6.2 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
3.1 µM

Target

M. luteus NBRC 12708

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC 10217 (MIC 6.2 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
6.2 µM

Target

S. cerevisiae NBRC 10217

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC 10217 (MIC 6.2 uM).
Evidence 9 Activity

Activity

MIC
Antiparasitic
3.1 µM

Target

Escherichia coli NBRC 14237

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC
Evidence 10 Activity

Activity

MIC
Antiparasitic
1.6 µM

Target

Staphylococcus aureus NBRC 12732

Source & Reference

DRAMP

Other

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC 10217 (MIC 6.2 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
3.1 µM

Target

M. luteus NBRC 12708

Source & Reference

DRAMP

Other

Active against E. coli NBRC 14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC 10217 (MIC 6.2 uM).
Evidence 12 Activity

Activity

MIC
Antiparasitic
6.2 µM

Target

S. cerevisiae NBRC 10217

Source & Reference

DRAMP

Other

14237 (MIC 3.1 uM), S. aureus NBRC 12732 (MIC 1.6 uM), M. luteus NBRC 12708 (MIC 3.1 uM), S. cerevisiae NBRC 10217 (MIC 6.2 uM).
Evidence 13 Activity

Activity

IC50
Hemolysis
25 µM
[Ref.28855917]IC50=25uM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Venom Anim Toxins Incl Trop Dis. 2017 Aug 29 23:40.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

(37.5±1.9)% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
(37.5±1.9)% Hemolysis | 100 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Isolation of biologically active peptides from the venom of Japanese carpenter bee, Xylocopa appendiculata. | J Venom Anim Toxins Incl Trop Dis | 2017
Evidence 15 Activity

Activity

30% Hemolysis
Toxicity
1000 µM
Hemolytic Cytotoxic
30% Hemolysis | 1000 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Peptidomic analysis of the venom of the solitary bee Xylocopa appendiculata circumvolans. | J Venom Anim Toxins Incl Trop Dis | 2017
Evidence 16 Activity

Activity

IC50
Toxicity
25 µM
Hemolytic
Hemolytic_activity: [Ref.28855917]IC50=25uM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Venom Anim Toxins Incl Trop Dis. 2017 Aug 29 23:40.
Evidence 17 Hemolysis

Activity

25 µM
IC50
[Ref.28855917]IC50=25uM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
J Venom Anim Toxins Incl Trop Dis. 2017 Aug 29 23:40.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.