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Peptide record

TPDB08442

Antibacterial Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08442
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 17-aa standard-residue multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
NIWKKIASIAKEVLKAL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C91H157N23O22
RDCQGHMFPTY
K
1925.39
10.55
4
1
10
+3
0.16
0.376
149.41
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
5500
2.86
2
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
1
E
0
Q
0
G
0
H
3
I
2
L
4
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 3 L: 2 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
17 reviewed residue count
C91H157N23O22 sequence-only estimate (linear, free termini)
1925.39 sequence-only estimate (linear, free termini)
10.55 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.16 sequence-only estimate (linear, free termini)
0.376 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
50% Hemolysis | 32 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
New potent antimicrobial peptides from the venom of Polistinae wasps and their analogs | Peptides | 2008
Evidence 2 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis