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Peptide record

TPDB08439

Antibacterial Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08439
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AVNIPFKVHLRCKAAFC
Physicochemical Analysis
C88H141N25O19S2
DEQGMSTWY
A
1917.36
9.92
4
0
9
+3
0.64
0.712
97.65
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
125
6.52
3
Residue Composition
number
3
A
1
R
1
N
0
D
2
C
0
E
0
Q
0
G
1
H
1
I
1
L
2
K
0
M
2
F
1
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 1 K: 2 M: 0 F: 2 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
17
C88H141N25O19S2
1917.36
9.92
+3
0.64
0.712
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
20 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli (MIC 20 uM). The peptide contains a canonical Kunitz-type protease inhibitor motif (-CKAAFC-), thereb
Evidence 2 Activity

Activity

MIC
Antifungal
20 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli (MIC 20 uM). The peptide contains a canonical Kunitz-type protease inhibitor motif (-CKAAFC-), thereb
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Kunitzins: Prototypes of a new class of protease inhibitor from the skin secretions of European and Asian frogs. | Biochem Biophys Res Commun | 2016