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Peptide record

TPDB08436

Antibacterial Anticancer Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08436
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP dbAMP 3.0 iACP-DRLF HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKLFKKIPFLHLAKKF
Physicochemical Analysis
C112H174N26O18
RNDCEQGMSTYV
K
2172.78
11.21
7
0
9
+6
-0.05
-0.176
97.65
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
253.13
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
3
L
6
K
0
M
3
F
1
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 3 K: 6 M: 0 F: 3 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
17
C112H174N26O18
2172.78
11.21
+6
-0.05
-0.176
Evidence Records 7 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
0% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001
Evidence 2 Activity

Activity

1% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
1% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001
Evidence 3 Activity

Activity

5% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
5% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001
Evidence 4 Activity

Activity

10% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
10% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001
Evidence 5 Activity

Activity

30% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
30% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001
Evidence 6 Activity

Activity

IC50
Toxicity
100.0 µM
Cytotoxic
IC50 | 100.0 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Antibacterial, antitumor and hemolytic activities of alpha-helical antibiotic peptide, P18 and its analogs. | J Pept Res | 2001
Evidence 7 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis