Back to search

Peptide record

TPDB08432

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08432
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab AFP-GFuse Antifungipept CAFPdb AVPpred-BWR dbAMP 3.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGMIPGLIGGLISAFK
Physicochemical Analysis
C84H136N18O19S1
RNDCEQHTWYV
G
1734.17
10.10
1
0
10
+1
-3.66
1.547
143.53
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
3
I
3
L
1
K
1
M
2
F
1
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 3 L: 3 K: 1 M: 1 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C84H136N18O19S1
1734.17
10.10
+1
-3.66
1.547
Evidence Records 45 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>320 µM

Target

E.coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus (MIC 5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM),
Evidence 2 Activity

Activity

MIC
Antibacterial
10-50 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus (MIC 5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoform
Evidence 3 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP DRAMP

Other

5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C.
Evidence 4 Activity

Activity

MIC
Antibacterial
100 µM

Target

C. parapsilosis ATCC22019

Source & Reference

dbAMP DRAMP

Other

. Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 u
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP DRAMP

Other

10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activ
Evidence 6 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP DRAMP

Other

M), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activity against initial adherence of C. albicans at 10
Evidence 7 Activity

Activity

MIC
Antibacterial
17.3 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP DRAMP

Other

inst the mature biofilm 400 uM ( Guilhelmelli F et al., 2016 ). Also active against Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram-
Evidence 8 Activity

Activity

MIC
Antibacterial
15.6 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP

Other

lmelli F et al., 2016 ). Also active against Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.
Evidence 9 Activity

Activity

MIC
Antibacterial
31.2 µg/mL

Target

B. cereus ATCC 11778

Source & Reference

dbAMP DRAMP

Other

Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.Typhimurium ATCC14028 (MIC > 250 ug/ml)
Evidence 10 Activity

Activity

MIC
Antibacterial
250 µg/mL

Target

K.pneumoniae ATCC 23357

Source & Reference

dbAMP DRAMP

Other

S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.Typhimurium ATCC14028 (MIC > 250 ug/ml), C.freundii ATCC 8090 (MIC > 250 ug/ml), and E
Evidence 11 Activity

Activity

MIC
Antifungal
>320 µM

Target

E.coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus (MIC 5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM),
Evidence 12 Activity

Activity

MIC
Antifungal
10-50 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus (MIC 5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoform
Evidence 13 Activity

Activity

MIC
Antifungal
6.25 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C.
Evidence 14 Activity

Activity

MIC
Antifungal
100 µM

Target

C. parapsilosis ATCC22019

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 u
Evidence 15 Activity

Activity

MIC
Antifungal
25 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activ
Evidence 16 Activity

Activity

MIC
Antifungal
12.5 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

M), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activity against initial adherence of C. albicans at 10
Evidence 17 Activity

Activity

MIC
Antifungal
17.3 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

inst the mature biofilm 400 uM ( Guilhelmelli F et al., 2016 ). Also active against Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram-
Evidence 18 Activity

Activity

MIC
Antifungal
15.6 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

lmelli F et al., 2016 ). Also active against Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.
Evidence 19 Activity

Activity

MIC
Antifungal
31.2 µg/mL

Target

B. cereus ATCC 11778

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.Typhimurium ATCC14028 (MIC > 250 ug/ml)
Evidence 20 Activity

Activity

MIC
Antifungal
250 µg/mL

Target

K.pneumoniae ATCC 23357

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.Typhimurium ATCC14028 (MIC > 250 ug/ml), C.freundii ATCC 8090 (MIC > 250 ug/ml), and E
Evidence 21 Activity

Activity

MIC
Antiparasitic
>320 µM

Target

E.coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
Active against S. aureus (MIC 5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM),
Evidence 22 Activity

Activity

MIC
Antiparasitic
10-50 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against S. aureus (MIC 5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoform
Evidence 23 Activity

Activity

MIC
Antiparasitic
6.25 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP 3.0 DRAMP

Other

5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C.
Evidence 24 Activity

Activity

MIC
Antiparasitic
100 µM

Target

C. parapsilosis ATCC22019

Source & Reference

dbAMP 3.0 DRAMP

Other

. Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 u
Evidence 25 Activity

Activity

MIC
Antiparasitic
25 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP 3.0 DRAMP

Other

10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activ
Evidence 26 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP 3.0 DRAMP

Other

M), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activity against initial adherence of C. albicans at 10
Evidence 27 Activity

Activity

MIC
Antiparasitic
17.3 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP 3.0 DRAMP

Other

inst the mature biofilm 400 uM ( Guilhelmelli F et al., 2016 ). Also active against Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram-
Evidence 28 Activity

Activity

MIC
Antiparasitic
15.6 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP 3.0 DRAMP

Other

lmelli F et al., 2016 ). Also active against Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.
Evidence 29 Activity

Activity

MIC
Antiparasitic
31.2 µg/mL

Target

B. cereus ATCC 11778

Source & Reference

dbAMP 3.0 DRAMP

Other

Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.Typhimurium ATCC14028 (MIC > 250 ug/ml)
Evidence 30 Activity

Activity

MIC
Antiparasitic
250 µg/mL

Target

K.pneumoniae ATCC 23357

Source & Reference

dbAMP 3.0 DRAMP

Other

S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.Typhimurium ATCC14028 (MIC > 250 ug/ml), C.freundii ATCC 8090 (MIC > 250 ug/ml), and E
Evidence 31 Activity

Activity

MIC
Antiviral
>320 µM

Target

E.coli

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
Active against S. aureus (MIC 5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM),
Evidence 32 Activity

Activity

MIC
Antiviral
10-50 µM

Target

Candida albicans SC5314

Source & Reference

dbAMP 3.0 DRAMP

Other

Active against S. aureus (MIC 5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoform
Evidence 33 Activity

Activity

MIC
Antiviral
6.25 µM

Target

C. tropicalis ATCC 750

Source & Reference

dbAMP 3.0 DRAMP

Other

5 uM MBC 10 uM), E.coli (MIC >320 uM). Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C.
Evidence 34 Activity

Activity

MIC
Antiviral
100 µM

Target

C. parapsilosis ATCC22019

Source & Reference

dbAMP 3.0 DRAMP

Other

. Active against C. albicans SC5314 (MIC 10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 u
Evidence 35 Activity

Activity

MIC
Antiviral
25 µM

Target

C. neoformans H99 serotype A

Source & Reference

dbAMP 3.0 DRAMP

Other

10-50 uM), C. tropicalis ATCC 750 (MIC 6.25 uM), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activ
Evidence 36 Activity

Activity

MIC
Antiviral
12.5 µM

Target

C. neoformans B3501 serotype D

Source & Reference

dbAMP 3.0 DRAMP

Other

M), C. parapsilosis ATCC22019 (MIC 100 uM), C. neoformans H99 serotype A (MIC 25 uM), and C. neoformans B3501 serotype D (MIC 12.5 uM). It also showed weak antibiofilmF activity against initial adherence of C. albicans at 10
Evidence 37 Activity

Activity

MIC
Antiviral
17.3 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP 3.0 DRAMP

Other

inst the mature biofilm 400 uM ( Guilhelmelli F et al., 2016 ). Also active against Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram-
Evidence 38 Activity

Activity

MIC
Antiviral
15.6 µg/mL

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP 3.0 DRAMP

Other

lmelli F et al., 2016 ). Also active against Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.
Evidence 39 Activity

Activity

MIC
Antiviral
31.2 µg/mL

Target

B. cereus ATCC 11778

Source & Reference

dbAMP 3.0 DRAMP

Other

Gram+ S. aureus ATCC 29213 (MIC 17.3 ug/ml), S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.Typhimurium ATCC14028 (MIC > 250 ug/ml)
Evidence 40 Activity

Activity

MIC
Antiviral
250 µg/mL

Target

K.pneumoniae ATCC 23357

Source & Reference

dbAMP 3.0 DRAMP

Other

S. epidermidis ATCC 12228 (MIC 15.6 ug/ml), B. cereus ATCC 11778 (MIC 31.2 ug/ml), Gram- K.pneumoniae ATCC 23357 (MIC 250 ug/ml), S.Typhimurium ATCC14028 (MIC > 250 ug/ml), C.freundii ATCC 8090 (MIC > 250 ug/ml), and E
Evidence 41 Activity

Activity

0% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
0% Hemolysis | 15 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities. | Biochimie | 2013
Evidence 42 Activity

Activity

86% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
86% Hemolysis | 40 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities. | Biochimie | 2013
Evidence 43 Activity

Activity

100% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
100% Hemolysis | 80 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities. | Biochimie | 2013
Evidence 44 Activity

Activity

48% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
48% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity of Scorpion Venom-Derived Antifungal Peptides against Planktonic Cells of Candida spp. and Cryptococcus neoformans and Candida albicans Biofilms. | Front Microbiol | 2016
Evidence 45 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.