Back to search

Peptide record

TPDB08429

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08429
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FFPLLFGALSSHLPKLF
Physicochemical Analysis
C99H144N20O20
RNDCEQIMTWYV
L
1934.35
10.10
2
0
10
+1
-4.37
1.159
120.59
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
5
L
1
K
0
M
4
F
2
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 5 K: 1 M: 0 F: 4 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
17
C99H144N20O20
1934.35
10.10
+1
-4.37
1.159
Evidence Records 27 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.75 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15
Evidence 2 Activity

Activity

MIC
Antibacterial
7.5 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aerug
Evidence 3 Activity

Activity

MIC
Antibacterial
7.5 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/
Evidence 4 Activity

Activity

MIC
Antibacterial
15 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

dbAMP DRAMP

Other

25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (
Evidence 5 Activity

Activity

MIC
Antibacterial
3.75 µg/mL

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP DRAMP

Other

5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (MIC 3.75 ug/ml). Updated 7/2020
Evidence 6 Activity

Activity

MIC
Antibacterial
3.75 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP

Other

ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (MIC 3.75 ug/ml). Updated 7/2020
Evidence 7 Activity

Activity

MIC
Antifungal
3.75 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15
Evidence 8 Activity

Activity

MIC
Antifungal
7.5 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aerug
Evidence 9 Activity

Activity

MIC
Antifungal
7.5 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/
Evidence 10 Activity

Activity

MIC
Antifungal
15 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (
Evidence 11 Activity

Activity

MIC
Antifungal
3.75 µg/mL

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (MIC 3.75 ug/ml). Updated 7/2020
Evidence 12 Activity

Activity

MIC
Antifungal
3.75 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (MIC 3.75 ug/ml). Updated 7/2020
Evidence 13 Activity

Activity

MIC
Antiparasitic
3.75 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15
Evidence 14 Activity

Activity

MIC
Antiparasitic
7.5 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aerug
Evidence 15 Activity

Activity

MIC
Antiparasitic
7.5 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/
Evidence 16 Activity

Activity

MIC
Antiparasitic
15 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

DRAMP

Other

25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (
Evidence 17 Activity

Activity

MIC
Antiparasitic
3.75 µg/mL

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

DRAMP

Other

5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (MIC 3.75 ug/ml). Updated 7/2020
Evidence 18 Activity

Activity

MIC
Antiparasitic
3.75 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

DRAMP

Other

ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (MIC 3.75 ug/ml). Updated 7/2020
Evidence 19 Activity

Activity

MIC
Antiviral
3.75 µg/mL

Target

Staphylococcus aureus ATCC25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15
Evidence 20 Activity

Activity

MIC
Antiviral
7.5 µg/mL

Target

Staphylococcus aureus ATCC43300

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aerug
Evidence 21 Activity

Activity

MIC
Antiviral
7.5 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

Active against S. aureus ATCC25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/
Evidence 22 Activity

Activity

MIC
Antiviral
15 µg/mL

Target

Escherichia coli ML-35P

Source & Reference

DRAMP

Other

25923 (MIC 3.75 ug/ml), S. aureus ATCC43300 (MIC 7.5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (
Evidence 23 Activity

Activity

MIC
Antiviral
3.75 µg/mL

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

DRAMP

Other

5 ug/ml), B. subtilis (MIC 7.5 ug/ml), E. coli ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (MIC 3.75 ug/ml). Updated 7/2020
Evidence 24 Activity

Activity

MIC
Antiviral
3.75 µg/mL

Target

Candida albicans ATCC2002

Source & Reference

DRAMP

Other

ML-35P (MIC 15 ug/ml), P. aeruginosa PA01, P. aeruginosa ATCC27853 (MIC 3.75 ug/ml), and C. albicans ATCC2002 (MIC 3.75 ug/ml). Updated 7/2020
Evidence 25 Activity

Activity

87% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
87% Hemolysis | 100 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010
Evidence 26 Activity

Activity

(80.43±0.97)% Degranulation
Toxicity
50 µg/mL
Cytotoxic
(80.43±0.97)% Degranulation | 50 | µg/mL | target cell: Rat mast cells

Target

Rat mast cells

Source & Reference

NA
DBAASP
Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010
Evidence 27 Hemolysis

Source & Reference

APD_complete APD_hemolytic PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.