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Peptide record

TPDB08403

Antibacterial Hemolysis Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08403
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
GFKRIVQAIKDFLRNLV
Physicochemical Analysis
C94H157N27O22
CEHMPSTWY
RILKFV
2017.45
11.47
4
1
9
+3
1.81
0.276
131.76
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
2
R
1
N
1
D
0
C
0
E
1
Q
1
G
0
H
2
I
2
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 1 H: 0 I: 2 L: 2 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
17
C94H157N27O22
2017.45
11.47
+3
1.81
0.276
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
15 µM

Target

Staphylococcus aureus USA300

Source & Reference

NA

Other

active against S. aureus USA300 (MIC 15 uM) and E. coli K-12 (MIC 60 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
60 µM

Target

Escherichia coli K-12

Source & Reference

NA

Other

active against S. aureus USA300 (MIC 15 uM) and E. coli K-12 (MIC 60 uM).
Evidence 3 Activity

Activity

60% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
60% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Amino Acid Composition Determines Peptide Activity Spectrum and Hot-Spot-Based Design of Merecidin. | Adv Biosyst | 2018
Evidence 4 Activity

Activity

100% Hemolysis
Toxicity
100-200 µM
Hemolytic Cytotoxic
100% Hemolysis | 100-200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Amino Acid Composition Determines Peptide Activity Spectrum and Hot-Spot-Based Design of Merecidin. | Adv Biosyst | 2018
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis