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Peptide record

TPDB08388

Antibacterial Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB08388
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RKLRRLKRKIAHKVKKY
Physicochemical Analysis
C101H185N37O19
NDCEQGMFPSTW
K
2221.82
12.43
11
0
6
+10
7.67
-1.635
91.76
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
67.06
1
Residue Composition
number
1
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
1
I
2
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 1 L: 2 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
17
C101H185N37O19
2221.82
12.43
+10
7.67
-1.635
Evidence Records 3 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity analysis of SMAP-29, a sheep leukocytes-derived antimicrobial peptide. | Biochem Biophys Res Commun | 2001
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >>100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11467858]Non-hemolysis at 100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2001 Jul 27 285(4):1046-51.