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Peptide record

TPDB08386

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

17 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB08386

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

FLPLVLGALSGILPKIL

FASTA

>TPDB08386|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=17
FLPLVLGALSGILPKIL

Formula C88H150N18O19

Absent Amino Acids RNDCEQHMTWY

Common Amino Acids L

Mass 1764.27

PI 10.10

Basic Residues 1

Acidic Residues 0

Hydrophobic Residues 11

Net Charge +1

Boman Index -3.17

Hydrophobicity 1.876

Aliphatic Index 206.47

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 6 K: 1 M: 0 F: 1 P: 2 S: 1 T: 0 W: 0 Y: 0 V: 1

Length

Formula

C88H150N18O19

Mass

1764.27

10.10

Net Charge

Boman Index

-3.17

Hydrophobicity

1.876

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 9.38 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against S. aureus (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.7 µg/mL

Target

Target Organism Pseudomonas aeruginosa PAO1

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against S. aureus (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8.26 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

s (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 9.38 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against S. aureus (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.7 µg/mL

Target

Target Organism Pseudomonas aeruginosa PAO1

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against S. aureus (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8.26 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

s (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 9.38 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against S. aureus (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 4.7 µg/mL

Target

Target Organism Pseudomonas aeruginosa PAO1

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8.26 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

s (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 9.38 µg/mL

Target

Target Organism B. subtilis

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets.

Evidence Text

Active against S. aureus (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 4.7 µg/mL

Target

Target Organism Pseudomonas aeruginosa PAO1

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against S. aureus (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8.26 µg/mL

Target

Target Organism Candida albicans ATCC2002

Source & Reference

Database Source DRAMP

Other

Evidence Text

s (MIC 4.69 um/ml), B. subtilis (MIC 9.38 ug/ml), P. aeruginosa PAO1 (MIC 4.7 ug/ml), and C. albicans ATCC2002 (MIC 8.26 ug/ml).

Evidence 13 Activity

Activity

Activity Endpoint 96% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

96% Hemolysis | 50 | µg/mL | target cell: Rabbit erythrocytes

Target

Target Cell Rabbit erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010

Evidence 14 Activity

Activity

Activity Endpoint (77.57±4.32)% Degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(77.57±4.32)% Degranulation | 50 | µg/mL | target cell: Rat mast cells

Target

Target Cell Rat mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Peptidomics and genomics analysis of novel antimicrobial peptides from the frog, Rana nigrovittata | Genomics | 2010

Evidence 15 Hemolysis

Source & Reference

source APD_complete APD_hemolytic PD_Hemolysis

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.