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Peptide record

TPDB08384

Anti-inflammatory Antibacterial Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08384
Anti-inflammatory Antibacterial Antifungal Toxicity
Anti-infective peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia AntiBP3 AFP-GFuse Antifungipept CAFPdb dbAMP
standard
No
A 16-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiBP3, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
KWAVRIIRKFIKGFIS
Physicochemical Analysis
C96H156N26O18
NDCEQHLMPTY
I
1962.46
12.43
5
0
9
+5
-0.72
0.425
121.88
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
280.26
1
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
4
I
0
L
3
K
0
M
2
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 4 L: 0 K: 3 M: 0 F: 2 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
16
C96H156N26O18
1962.46
12.43
+5
-0.72
0.425
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

Escherichia coli ATCC 25922 and

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli ATCC 25922 and 4 strains (MIC 1-2 uM), P. aeruginosa ATCC 27853 and 8 strains (MIC 1.67-8.2 uM), S. aureus ATCC 25923 and 3 str
Evidence 2 Activity

Activity

MIC
Antibacterial
1.67-8.2 µM

Target

Pseudomonas aeruginosa ATCC 27853 and

Source & Reference

dbAMP

Other

Active against E. coli ATCC 25922 and 4 strains (MIC 1-2 uM), P. aeruginosa ATCC 27853 and 8 strains (MIC 1.67-8.2 uM), S. aureus ATCC 25923 and 3 strains (MIC 1-4.1 uM), E. faecalis ATCC 29212 (MIC 2-8.2 uM)
Evidence 3 Activity

Activity

MIC
Antibacterial
1-4.1 µM

Target

Staphylococcus aureus ATCC 25923 and

Source & Reference

dbAMP

Other

922 and 4 strains (MIC 1-2 uM), P. aeruginosa ATCC 27853 and 8 strains (MIC 1.67-8.2 uM), S. aureus ATCC 25923 and 3 strains (MIC 1-4.1 uM), E. faecalis ATCC 29212 (MIC 2-8.2 uM). In a different paper,it is showed to be active ag
Evidence 4 Activity

Activity

MIC
Antibacterial
2-8.2 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP

Other

27853 and 8 strains (MIC 1.67-8.2 uM), S. aureus ATCC 25923 and 3 strains (MIC 1-4.1 uM), E. faecalis ATCC 29212 (MIC 2-8.2 uM). In a different paper,it is showed to be active against S. epidermidis (MIC 1 uM), T. rub
Evidence 5 Activity

Activity

MIC
Antibacterial
1 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP

Other

aecalis ATCC 29212 (MIC 2-8.2 uM). In a different paper,it is showed to be active against S. epidermidis (MIC 1 uM), T. rubrum (MIC 8 uM), and C. albicans (MIC 1.67 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
8 µM

Target

T. rubrum

Source & Reference

dbAMP

Other

.2 uM). In a different paper,it is showed to be active against S. epidermidis (MIC 1 uM), T. rubrum (MIC 8 uM), and C. albicans (MIC 1.67 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
1.67 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

er,it is showed to be active against S. epidermidis (MIC 1 uM), T. rubrum (MIC 8 uM), and C. albicans (MIC 1.67 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
1-2 µM

Target

Escherichia coli ATCC 25922 and

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli ATCC 25922 and 4 strains (MIC 1-2 uM), P. aeruginosa ATCC 27853 and 8 strains (MIC 1.67-8.2 uM), S. aureus ATCC 25923 and 3 str
Evidence 9 Activity

Activity

MIC
Antifungal
1.67-8.2 µM

Target

Pseudomonas aeruginosa ATCC 27853 and

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC 25922 and 4 strains (MIC 1-2 uM), P. aeruginosa ATCC 27853 and 8 strains (MIC 1.67-8.2 uM), S. aureus ATCC 25923 and 3 strains (MIC 1-4.1 uM), E. faecalis ATCC 29212 (MIC 2-8.2 uM)
Evidence 10 Activity

Activity

MIC
Antifungal
1-4.1 µM

Target

Staphylococcus aureus ATCC 25923 and

Source & Reference

dbAMP CAFPdb Antifungipept

Other

922 and 4 strains (MIC 1-2 uM), P. aeruginosa ATCC 27853 and 8 strains (MIC 1.67-8.2 uM), S. aureus ATCC 25923 and 3 strains (MIC 1-4.1 uM), E. faecalis ATCC 29212 (MIC 2-8.2 uM). In a different paper,it is showed to be active ag
Evidence 11 Activity

Activity

MIC
Antifungal
2-8.2 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP CAFPdb Antifungipept

Other

27853 and 8 strains (MIC 1.67-8.2 uM), S. aureus ATCC 25923 and 3 strains (MIC 1-4.1 uM), E. faecalis ATCC 29212 (MIC 2-8.2 uM). In a different paper,it is showed to be active against S. epidermidis (MIC 1 uM), T. rub
Evidence 12 Activity

Activity

MIC
Antifungal
1 µM

Target

Staphylococcus epidermidis

Source & Reference

dbAMP CAFPdb Antifungipept

Other

aecalis ATCC 29212 (MIC 2-8.2 uM). In a different paper,it is showed to be active against S. epidermidis (MIC 1 uM), T. rubrum (MIC 8 uM), and C. albicans (MIC 1.67 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
8 µM

Target

T. rubrum

Source & Reference

dbAMP CAFPdb Antifungipept

Other

.2 uM). In a different paper,it is showed to be active against S. epidermidis (MIC 1 uM), T. rubrum (MIC 8 uM), and C. albicans (MIC 1.67 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
1.67 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

er,it is showed to be active against S. epidermidis (MIC 1 uM), T. rubrum (MIC 8 uM), and C. albicans (MIC 1.67 uM).
Evidence 15 Activity

Activity

50% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
50% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity. | PLoS One | 2019
Evidence 16 Activity

Activity

40% Killing
Toxicity
10 µM
Cytotoxic
40% Killing | 10 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity. | PLoS One | 2019
Evidence 17 Activity

Activity

7% Killing
Toxicity
10 µM
Cytotoxic
7% Killing | 10 | µM | target cell: Murine macrophage cells J774A.1

Target

Murine macrophage cells J774A.1

Source & Reference

NA
DBAASP
Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity. | PLoS One | 2019
Evidence 18 Activity

Activity

80% Killing
Toxicity
100 µM
Cytotoxic
80% Killing | 100 | µM | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
Intragenic antimicrobial peptides (IAPs) from human proteins with potent antimicrobial and anti-inflammatory activity. | PLoS One | 2019
Evidence 19 Activity

Activity

<5% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 32 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptide Hs02 with rapid bactericidal, anti-biofilm, and anti-inflammatory activity against carbapenem-resistant Klebsiella pneumoniae and Escherichia coli | Microbiol Spectr | 2024