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Peptide record

TPDB08383

Antibacterial Antifungal Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08383
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GLWRVIRKVASVIGGL
Physicochemical Analysis
C80H138N24O18
NDCEQHMFPTY
GV
1724.13
12.41
3
0
9
+3
-0.78
0.950
158.12
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
319.00
1
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
3
G
0
H
2
I
2
L
1
K
0
M
0
F
0
P
1
S
0
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 2 L: 2 K: 1 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 3
Chemical Descriptors
16
C80H138N24O18
1724.13
12.41
+3
-0.78
0.950
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
26.7 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 26.7 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Understanding interactions of Citropin 1.1 analogues with model membranes and their influence on biological activity. | Peptides | 2019
Evidence 2 Activity

Activity

IC50
Toxicity
18.10 µg/mL
Cytotoxic
IC50 | 18.10 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Understanding interactions of Citropin 1.1 analogues with model membranes and their influence on biological activity. | Peptides | 2019
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis