TPDB

3D PDB MODEL

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TPDB ID TPDB08376

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

KKLLKKPLLKKLLKKL

FASTA

>TPDB08376|Antibacterial;Toxicity|length=16
KKLLKKPLLKKLLKKL

Formula C95H182N24O17

Absent Amino Acids ARNDCEQGHIMFSTWYV

Common Amino Acids K

Mass 1932.64

PI 11.36

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 7

Net Charge +8

Boman Index 4.45

Hydrophobicity -0.388

Aliphatic Index 170.62

Half Life

Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

7

L

8

K

0

M

0

F

1

P

0

S

0

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 7 K: 8 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

16

Formula

C95H182N24O17

Mass

1932.64

PI

11.36

Net Charge

+8

Boman Index

4.45

Hydrophobicity

-0.388

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism Pseudomonas aeruginosa ATCC 27853

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- P. aeruginosa ATCC 27853 (MIC 1.56 uM), A. baumannii KCTC 2508 (MIC 3.13 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. s

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.13 µM

Target

Target Organism A. baumannii KCTC 2508

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- P. aeruginosa ATCC 27853 (MIC 1.56 uM), A. baumannii KCTC 2508 (MIC 3.13 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism Staphylococcus aureus ATCC 25923

Source & Reference

Database Source NA

Other

Evidence Text

Gram- P. aeruginosa ATCC 27853 (MIC 1.56 uM), A. baumannii KCTC 2508 (MIC 3.13 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism B. subtilis KCTC 2217

Source & Reference

Database Source NA

Other

Evidence Text

uM), A. baumannii KCTC 2508 (MIC 3.13 uM), Gram+ S. aureus ATCC 25923 (MIC 1.56 uM), and B. subtilis KCTC 2217 (MIC 1.56 uM).

Evidence 5 Activity

Activity

Activity Endpoint 0% Killing

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Cytotoxic

Toxicity Raw

0% Killing | 100 | µM | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Mechanism of action of antimicrobial peptide P5 truncations against Pseudomonas aeruginosa and Staphylococcus aureus | AMB Express | 2019