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Peptide record

TPDB08375

Antibacterial Cell-penetrating Peptides Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08375
Antibacterial Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CPPsite3.0 PD_Hemolysis
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LKKLLKLGKKLLKLAG
Physicochemical Analysis
C85H162N22O17
RNDCEQHIMFPSTWYV
L
1764.36
11.21
6
0
8
+6
1.87
0.262
176.88
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
7
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 7 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C85H162N22O17
1764.36
11.21
+6
1.87
0.262
Evidence Records 4 records
Evidence 1 Activity

Activity

MHC10
Hemolysis
10 µM
[Ref.23894079] MHC10=10 µM against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
ChemMedChem. 2013 Oct 8(10):1638-42. doi: 10.1002/cmdc.201300264.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

10% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
10% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides. | ChemMedChem | 2013
Evidence 3 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23894079] MHC10=10 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
ChemMedChem. 2013 Oct 8(10):1638-42. doi: 10.1002/cmdc.201300264.
Evidence 4 Hemolysis

Activity

10 µM
MHC10
[Ref.23894079] MHC10=10 µM against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
ChemMedChem. 2013 Oct 8(10):1638-42. doi: 10.1002/cmdc.201300264.
DRAMP4
PD_Hemolysis