Back to search

Peptide record

TPDB08369

W/R RW16 Antibacterial Cell-penetrating Peptides Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08369
W/R RW16
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CellPPD CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CellPPD, and other sources, with an available 3D structural model.
Sequence
RRWRRWWRRWWRRWRR
Physicochemical Analysis
C126H182N52O17
ANDCEQGHILKMFPSTYV
R
2697.17
13.35
10
0
6
+10
-3.00
-3.150
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
33000
1223.50
0
Residue Composition
number
0
A
10
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
6
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 6 Y: 0 V: 0
Chemical Descriptors
16
C126H182N52O17
2697.17
13.35
+10
-3.00
-3.150
Free
L
Amphipathic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Protein derived
In vitro
CCSGGGHHHHHHHHTC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Standard and Annexin 2-GFP transfected MDCK cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Amphipathic
Synthetic
Nanoparticle (PMS labelled with the fluorescent probe di-4-ANEPPDHQ)
Number of protrusions observed when PMS were incubated with the longer amphipathic peptide RW16 was smaller compared to RW9
Endocytosis, direct translocation or physical endocytosis
In vitro
CCSGGGHHHHHHHHTC
Additional Detail Fields 1 fields
CCSGGGHHHHHHHHTC