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Peptide record

TPDB08368

Antibacterial Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08368
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 16-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
KWYKKWYKKWYKKWYK
Physicochemical Analysis
C128H174N28O21
ARNDCEQGHILMFPSTV
K
2440.96
10.53
8
0
8
+8
-3.24
-2.500
0.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27960
1145.45
4
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
8
K
0
M
0
F
0
P
0
S
0
T
4
W
4
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 8 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 4 V: 0
Chemical Descriptors
16
C128H174N28O21
2440.96
10.53
+8
-3.24
-2.500
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
67 µM
Cytotoxic
50% Cytotoxicity | 67 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Cell-selectivity of tryptophan and tyrosine in amphiphilic ?-helical antimicrobial peptides against drug-resistant bacteria. | Biochem Biophys Res Commun | 2018
Evidence 2 Activity

Activity

7% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
7% Hemolysis | 125 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Cell-selectivity of tryptophan and tyrosine in amphiphilic ?-helical antimicrobial peptides against drug-resistant bacteria. | Biochem Biophys Res Commun | 2018
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
250 µM
Hemolytic Cytotoxic
10% Hemolysis | 250 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Cell-selectivity of tryptophan and tyrosine in amphiphilic ?-helical antimicrobial peptides against drug-resistant bacteria. | Biochem Biophys Res Commun | 2018
Evidence 4 Activity

Activity

75.2% Killing
Toxicity
100 µM
Cytotoxic
75.2% Killing | 100 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Cell-selectivity of tryptophan and tyrosine in amphiphilic ?-helical antimicrobial peptides against drug-resistant bacteria. | Biochem Biophys Res Commun | 2018