Back to search

Peptide record

TPDB08367

Antibacterial Cell-penetrating Peptides Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08367
Antibacterial Cell-penetrating Peptides Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CPPsite3.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Cell-penetrating Peptides, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LKKLLKLEKKLLKLAG
Physicochemical Analysis
C88H166N22O19
RNDCQHIMFPSTWYV
L
1836.42
10.82
6
1
8
+5
3.88
0.069
176.88
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
0
I
7
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 7 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C88H166N22O19
1836.42
10.82
+5
3.88
0.069
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
320 µM
Hemolytic Cytotoxic
10% Hemolysis | 320 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides. | ChemMedChem | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23894079] MHC10=320 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
ChemMedChem. 2013 Oct 8(10):1638-42. doi: 10.1002/cmdc.201300264.