Back to search

Peptide record

TPDB08360

Antibacterial Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB08360
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ALWKNMLKGIGKLAGK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C80H138N22O18S1
RDCEQHFPSTYV
K
1728.17
11.00
4
0
8
+4
-0.12
0.012
110.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
5500
3.18
1
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
1
I
3
L
4
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 1 L: 3 K: 4 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
16 reviewed residue count
C80H138N22O18S1 sequence-only estimate (linear, free termini)
1728.17 sequence-only estimate (linear, free termini)
11.00 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
-0.12 sequence-only estimate (linear, free termini)
0.012 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

100% Hemolysis
Toxicity
>150 µM
Hemolytic Cytotoxic
100% Hemolysis | >150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The vertebrate peptide antibiotics dermaseptins have overlapping structural features but target specific microorganisms. | J Biol Chem | 1994