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Peptide record

TPDB08359

Antibacterial Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB08359
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb
standard
No
A 16-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GIMSSLMKKLKKHIAK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C81H149N23O19S2
RNDCEQFPTWYV
K
1813.34
11.12
6
0
7
+5
0.76
-0.156
103.75
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
2
I
2
L
5
K
2
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 2 L: 2 K: 5 M: 2 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16 reviewed residue count
C81H149N23O19S2 sequence-only estimate (linear, free termini)
1813.34 sequence-only estimate (linear, free termini)
11.12 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
0.76 sequence-only estimate (linear, free termini)
-0.156 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>400 µM
Hemolytic Cytotoxic
50% Hemolysis | >400 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide from the Wild Bee Hylaeus signatus Venom and Its Analogues: Structure-Activity Study and Synergistic Effect with Antibiotics. | J Nat Prod | 2016
Evidence 2 Activity

Activity

LC50
Toxicity
400 µM
Hemolytic
Hemolytic_activity: [Ref.26998557] LC50>400 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
J Nat Prod. 2016 Apr 22 79(4):1073-83. doi: 10.1021/acs.jnatprod.5b01129.